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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Celf4tm1.1Frk
targeted mutation 1.1, Wayne N Frankel
MGI:5425629
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Celf4tm1.1Frk/Celf4tm1.1Frk
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129 * C57BL/6J MGI:6194636
cn2
 		Celf4tm1.1Frk/Celf4tm1.1Frk
Tg(Camk2a-cre)1Lfr/0 		involves: 129 * C57BL/6J MGI:6194751
cn3
 		Celf4tm1.1Frk/Celf4tm1.1Frk
Emx1tm1(cre)Krj/? 		involves: 129 * C57BL/6J MGI:6194753
cn4
 		Celf4tm1.1Frk/Celf4tm1.1Frk
Tg(Slc32a1-cre)2.1Hzo/0 		involves: 129 * C57BL/6J * FVB MGI:6194750


Genotype
MGI:6194636
cn1
Allelic
Composition		 Celf4tm1.1Frk/Celf4tm1.1Frk
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4tm1.1Frk mutation (2 available); any Celf4 mutation (27 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
convulsive seizures ( J:181678 )
• tamoxifen-induced deletion at 7 weeks of age is sufficient to cause a lowered threshold for handling-associated convulsive seizures
abnormal spike wave discharge ( J:181678 )
• tamoxifen-induced cre excision of Celf4 must occur by 1 day of age in order to develop a high incidence of spike wave discharge, and induced deletion at 5 to 7 days of age or later fails to result in increased absence seizures

nervous system
convulsive seizures ( J:181678 )
• tamoxifen-induced deletion at 7 weeks of age is sufficient to cause a lowered threshold for handling-associated convulsive seizures
abnormal spike wave discharge ( J:181678 )
• tamoxifen-induced cre excision of Celf4 must occur by 1 day of age in order to develop a high incidence of spike wave discharge, and induced deletion at 5 to 7 days of age or later fails to result in increased absence seizures




Genotype
MGI:6194751
cn2
Allelic
Composition		 Celf4tm1.1Frk/Celf4tm1.1Frk
Tg(Camk2a-cre)1Lfr/0
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4tm1.1Frk mutation (2 available); any Celf4 mutation (27 available)
Tg(Camk2a-cre)1Lfr mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased susceptibility to induction of seizure by inducing agent ( J:194671 )
• seizure threshold measured by ECT test in this conditional null shows an increase in both males and females

nervous system
increased susceptibility to induction of seizure by inducing agent ( J:194671 )
• seizure threshold measured by ECT test in this conditional null shows an increase in both males and females




Genotype
MGI:6194753
cn3
Allelic
Composition		 Celf4tm1.1Frk/Celf4tm1.1Frk
Emx1tm1(cre)Krj/?
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4tm1.1Frk mutation (2 available); any Celf4 mutation (27 available)
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased susceptibility to induction of seizure by inducing agent ( J:19671 )
• seizure threshold measured by ECT test in this conditional null shows an increase in both males and females

nervous system
increased susceptibility to induction of seizure by inducing agent ( J:19671 )
• seizure threshold measured by ECT test in this conditional null shows an increase in both males and females




Genotype
MGI:6194750
cn4
Allelic
Composition		 Celf4tm1.1Frk/Celf4tm1.1Frk
Tg(Slc32a1-cre)2.1Hzo/0
Genetic
Background		 involves: 129 * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4tm1.1Frk mutation (2 available); any Celf4 mutation (27 available)
Tg(Slc32a1-cre)2.1Hzo mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased susceptibility to induction of seizure by inducing agent ( J:194671 )
• seizure threshold measured by ECT test in this conditional null shows a decrease in both males and females

nervous system
decreased susceptibility to induction of seizure by inducing agent ( J:194671 )
• seizure threshold measured by ECT test in this conditional null shows a decrease in both males and females




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory