behavior/neurological
• Background Sensitivity: as early as 87 days of age homozygotes begin having tonic-clonic seizures either spontaneously or as a result of routine handling, and 46% develop convulsive seizures by 175 days of age
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• Background Sensitivity: absence seizures indicated by spike wave discharge in the EEG are identified in homozygotes on the 129S1 background and the B6 x 129 hybrid background
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growth/size/body
• Background Sensitivity: homozygotes on the 129S1 background are usually smaller than wild-type or heterozygous siblings, yet have increased viability relative to those on the C57BL/6J congenic background
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nervous system
• Background Sensitivity: as early as 87 days of age homozygotes begin having tonic-clonic seizures either spontaneously or as a result of routine handling, and 46% develop convulsive seizures by 175 days of age
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• Background Sensitivity: absence seizures indicated by spike wave discharge in the EEG are identified in homozygotes on the 129S1 background and the B6 x 129 hybrid background
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• whole-cell patch-clamp recordings at the soma of layer V pyramidal neurons of the visual cortex, assessed between 14 and 21 days of age, show that the frequency and amplitude of mEPSCs is increased relative to wildtype controls, but no change in mEPSC kinetics and no abnormalities in mIPSCs
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mortality/aging
• Background Sensitivity: at wean age, only 18% of pups from heterozygous intercrosses are homozygotes, which is less severe than that found in C57BL/6J congenic homozygotes
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