Phenotypes associated with this allele

• Allele Symbol: Smad7^tm1.1Ink
• Allele Name: targeted mutation 1.1, Ingo Kleiter
• Allele ID: MGI:5426017
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Smad7^tm1.1Ink/Smad7^tm1.1Ink Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2	MGI:5426211

Genotype
MGI:5426211

cn1

• Allelic Composition: Smad7^tm1.1Ink/Smad7^tm1.1Ink; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:184670 )

N • mice exhibit a largely normal distribution of lymphocyte populations

decreased T cell proliferation ( J:184670 )

• of re-stimulated T cells from MOG 35-55 treated mice

• of T cells stimulated with concanavalin

abnormal T-helper 1 cell differentiation ( J:184670 )

• decreased

decreased activated T cell number ( J:184670 )

• small decrease of CD4+ and CD8+ activated T cells in the peripheral lymphoid organs

decreased interferon-gamma secretion ( J:184670 )

• in splenocytes from MOG 35-55-treated mice

decreased interleukin-9 secretion ( J:184670 )

• during Th17 differentiation

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:184670 )

• mice treated with MOG 35-55 exhibit reduced incidence and severity (reduced inflammation, demyelination and axonal damage) of experimental autoimmune encephalomyelitis despite slightly earlier onset of paralysis compared with control mice

homeostasis/metabolism

increased transforming growth factor beta level ( J:184670 )

• in T-cells stimulated with anti-CD3/CD28 and IL2 compared with similarly treated T cells from Tg(CD2-Smad7) mice

behavior/neurological

paralysis ( J:184670 )

• ealier in mice treated with MOG 35-55 compared with control mice

hematopoietic system

decreased T cell proliferation ( J:184670 )

• of re-stimulated T cells from MOG 35-55 treated mice

• of T cells stimulated with concanavalin

abnormal T-helper 1 cell differentiation ( J:184670 )

• decreased

decreased activated T cell number ( J:184670 )

• small decrease of CD4+ and CD8+ activated T cells in the peripheral lymphoid organs

cellular

decreased T cell proliferation ( J:184670 )

• of re-stimulated T cells from MOG 35-55 treated mice

• of T cells stimulated with concanavalin