Phenotypes associated with this allele

• Allele Symbol: Tg(Cd2-Smad7)#Chbe
• Allele Name: transgene insertion, Christoph Becker
• Allele ID: MGI:5426209
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Cd2-Smad7)#Chbe/0	involves: C57BL/6	MGI:5426212

Genotype
MGI:5426212

tg1

• Allelic Composition: Tg(Cd2-Smad7)#Chbe/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:184670 )

• in mice treated with MOG 35-55

immune system

abnormal T-helper 1 cell differentiation ( J:184670 )

• increased

increased interferon-gamma secretion ( J:184670 )

• in T cells from MOG 35-55-treated mice re-stimulated with anti-CD3/CD28 T cells

decreased interleukin-10 secretion ( J:184670 )

• during Th17 differentiation

decreased interleukin-17 secretion ( J:184670 )

• decreased IL17a secretion from splenocytes from MOG 35-55-treated mice

decreased interleukin-9 secretion ( J:184670 )

• during Th17 differentiation

increased susceptibility to experimental autoimmune encephalomyelitis ( J:184670 )

• mice treated with MOG 35-55 exhibit increased mortality and increased maximum clinical score compared with control mice

homeostasis/metabolism

decreased transforming growth factor beta level ( J:184670 )

• in T-cells stimulated with anti-CD3/CD28 and IL2 compared with similarly treated T cells from Smad7^tm1.1Ink/Smad7^tm1.1Ink Tg(Cd4-cre)1Cwi mice

hematopoietic system

abnormal T-helper 1 cell differentiation ( J:184670 )

• increased