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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il17rbtm1Tgi
targeted mutation 1, Masaru Taniguchi
MGI:5426267
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il17rbtm1Tgi/Il17rbtm1Tgi B6.Cg-Il17rbtm1Tgi MGI:5426349
hm2
 		Il17rbtm1Tgi/Il17rbtm1Tgi C.Cg-Il17rbtm1Tgi MGI:5426350
hm3
 		Il17rbtm1Tgi/Il17rbtm1Tgi Not Specified MGI:5767210
ht4
 		Il17rbtm1Tgi/Il17rb+ Not Specified MGI:5767211


Genotype
MGI:5426349
hm1
Allelic
Composition		 Il17rbtm1Tgi/Il17rbtm1Tgi
Genetic
Background		 B6.Cg-Il17rbtm1Tgi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17rbtm1Tgi mutation (2 available); any Il17rb mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:184570 )
• slight decrease in invariant NK T cells in the spleen
abnormal interleukin secretion ( J:184570 )
• invariant NK T cells stimulated with alpha-GalCer or co-cultured with GM-CSF-induced bone marrow exhibit decreased secretion of Il9, IL10, IL13, IL17 and IL22 in derived dendritic cells treated with alpha-GalCer compared with control cells
• invariant NK T cells co-cultured with bone marrow-derived dendritic cells from Cd1d1tm1Luc homozygotes fail to secrete any interleukins
decreased interleukin-10 secretion ( J:184570 )
• in invariant NK T cells co-cultured with GM-CSF-induced bone marrow derived dendritic cells treated with alpha-GalCer
• in invariant NK T cells stimulated with alpha-GalCer
decreased interleukin-13 secretion ( J:184570 )
• in invariant NK T cells co-cultured with GM-CSF-induced bone marrow derived dendritic cells treated with alpha-GalCer
• in invariant NK T cells stimulated with alpha-GalCer
decreased interleukin-17 secretion ( J:184570 )
• in invariant NK T cells co-cultured with GM-CSF-induced bone marrow derived dendritic cells treated with alpha-GalCer
• in invariant NK T cells stimulated with alpha-GalCer
decreased interleukin-9 secretion ( J:184570 )
• in invariant NK T cells co-cultured with GM-CSF-induced bone marrow derived dendritic cells treated with alpha-GalCer
• in invariant NK T cells stimulated with alpha-GalCer

hematopoietic system
decreased NK T cell number ( J:184570 )
• slight decrease in invariant NK T cells in the spleen




Genotype
MGI:5426350
hm2
Allelic
Composition		 Il17rbtm1Tgi/Il17rbtm1Tgi
Genetic
Background		 C.Cg-Il17rbtm1Tgi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17rbtm1Tgi mutation (2 available); any Il17rb mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Il17rbtm1Tgi/Il17rbtm1Tgi and Tcra-Jtm1Tgi/Tcra-Jtm1Tgi mice fail to exhibit airway hyperactivity in response to respiratory syncytial virus exposure

immune system
abnormal interleukin secretion ( J:184570 )
• the bronchoalveolar lavage fluid from mice exposed to respiratory syncytial virus fail to exhibit an increase in IL5, IL9, IL10, IL13, IL17A and IL22 unlike wild-type mice
decreased interleukin-13 secretion ( J:184570 )
• the bronchoalveolar lavage fluid from mice exposed to respiratory syncytial virus
decreased interleukin-17 secretion ( J:184570 )
• the bronchoalveolar lavage fluid from mice exposed to respiratory syncytial virus
decreased interleukin-5 secretion ( J:184570 )
• the bronchoalveolar lavage fluid from mice exposed to respiratory syncytial virus
decreased interleukin-9 secretion ( J:184570 )
• the bronchoalveolar lavage fluid from mice exposed to respiratory syncytial virus

respiratory system
decreased airway responsiveness ( J:184570 )
• in response to respiratory syncytial virus exposure, mice fail to exhibit airway hyperreactivity unlike wild-type mice




Genotype
MGI:5767210
hm3
Allelic
Composition		 Il17rbtm1Tgi/Il17rbtm1Tgi
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17rbtm1Tgi mutation (2 available); any Il17rb mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to induced colitis ( J:229778 )
• DSS-treated mice exhibit reduced weight loss compared with wild-type mice
• however, bone marrow transplant experiments reveal that deficiency only in the leukocytes leads to normal weight loss while mice lacking Il17rb in non-immune cells exhibit protection from DSS colitis

growth/size/body
decreased susceptibility to weight loss ( J:229778 )
• in DSS-treated mice

digestive/alimentary system
decreased susceptibility to induced colitis ( J:229778 )
• DSS-treated mice exhibit reduced weight loss compared with wild-type mice
• however, bone marrow transplant experiments reveal that deficiency only in the leukocytes leads to normal weight loss while mice lacking Il17rb in non-immune cells exhibit protection from DSS colitis




Genotype
MGI:5767211
ht4
Allelic
Composition		 Il17rbtm1Tgi/Il17rb+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17rbtm1Tgi mutation (2 available); any Il17rb mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to induced colitis ( J:229778 )
• DSS-treated mice exhibit reduced weight loss compared with wild-type mice

growth/size/body
decreased susceptibility to weight loss ( J:229778 )
• in DSS-treated mice

digestive/alimentary system
decreased susceptibility to induced colitis ( J:229778 )
• DSS-treated mice exhibit reduced weight loss compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory