Phenotypes associated with this allele

• Allele Symbol: Spns2^tm1.1Nmoc
• Allele Name: targeted mutation 1.1, Naoki Mochizuki
• Allele ID: MGI:5426392
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Spns2^tm1.1Nmoc/Spns2^tm1.1Nmoc Tg(Tek-cre)1Ywa/0	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL	MGI:5426398

Genotype
MGI:5426398

cn1

• Allelic Composition: Spns2^tm1.1Nmoc/Spns2^tm1.1Nmoc; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased mature B cell number ( J:184558 )

• in the bone marrow

abnormal effector T cell morphology ( J:184558 )

• mice exhibit reduced mature T cells in the peripheral lymph nodes compared with wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:184558 )

• in the blood, peripheral lymph nodes and spleen

increased CD4-positive, alpha-beta T cell number ( J:184558 )

• in the thymus, but to a lesser extent than in Spns2^tm1.2Nmoc homozygotes

decreased CD8-positive, alpha-beta T cell number ( J:184558 )

• in the blood, peripheral lymph nodes and spleen

increased CD8-positive, alpha-beta T cell number ( J:184558 )

• in the thymus, but to a lesser extent than in Spns2^tm1.2Nmoc homozygotes

abnormal B cell physiology ( J:184558 )

• immature B cells exhibit impaired egression from the bone marrow compared to in wild-type mice

abnormal T cell physiology ( J:184558 )

• single positive T cells exhibit impaired egression from the thymus compared with wild-type cells

vision/eye

vision/eye phenotype ( J:184558 )

N • mice do not develop symblepharon

hematopoietic system

decreased mature B cell number ( J:184558 )

• in the bone marrow

abnormal effector T cell morphology ( J:184558 )

• mice exhibit reduced mature T cells in the peripheral lymph nodes compared with wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:184558 )

• in the blood, peripheral lymph nodes and spleen

increased CD4-positive, alpha-beta T cell number ( J:184558 )

• in the thymus, but to a lesser extent than in Spns2^tm1.2Nmoc homozygotes

decreased CD8-positive, alpha-beta T cell number ( J:184558 )

• in the blood, peripheral lymph nodes and spleen

increased CD8-positive, alpha-beta T cell number ( J:184558 )

• in the thymus, but to a lesser extent than in Spns2^tm1.2Nmoc homozygotes

abnormal B cell physiology ( J:184558 )

• immature B cells exhibit impaired egression from the bone marrow compared to in wild-type mice

abnormal T cell physiology ( J:184558 )

• single positive T cells exhibit impaired egression from the thymus compared with wild-type cells