Phenotypes associated with this allele

• Allele Symbol: Dck^memi
• Allele Name: memi
• Allele ID: MGI:5426400
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dck^memi/Dck^memi	C57BL/6J-Dck^memi	MGI:5426402

Genotype
MGI:5426402

hm1

• Allelic Composition: Dck^memi/Dck^memi
• Genetic Background: C57BL/6J-Dck^memi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell apoptosis ( J:184080 )

• both cell-intrinsic and -extrinsic

increased T cell proliferation ( J:184080 )

• in DN3 cells

• in peripheral T lymphocytes

• both cell-intrinsic and -extrinsic

small thymus ( J:184080 )

thymus hypoplasia ( J:184080 )

enlarged spleen ( J:184080 )

abnormal T cell differentiation ( J:184080 )

• incomplete developmental block between DN3 and DN4

decreased B cell number ( J:184080 )

• in the blood and spleen

increased effector memory CD4-positive, alpha-beta T cell number ( J:184080 )

decreased CD4-positive, alpha-beta T cell number ( J:184080 )

• in the blood and spleen

increased effector memory CD8-positive, alpha-beta T cell number ( J:184080 )

abnormal myeloid leukocyte morphology ( J:184080 )

• mice exhibit an increase in cells of myeloid origins (CD11c/Itgax+, CD11b/Itgam+ and Gr-1/Ly6g+) in the blood and spleen compared with wild-type mice

abnormal response to infection ( J:184080 )

• mice exposed to LCMV are enriched for effector cells and deprived of memory precursors compared with wild-type mice

cellular

increased T cell apoptosis ( J:184080 )

• both cell-intrinsic and -extrinsic

increased T cell proliferation ( J:184080 )

• in DN3 cells

• in peripheral T lymphocytes

• both cell-intrinsic and -extrinsic

hematopoietic system

increased T cell apoptosis ( J:184080 )

• both cell-intrinsic and -extrinsic

increased T cell proliferation ( J:184080 )

• in DN3 cells

• in peripheral T lymphocytes

• both cell-intrinsic and -extrinsic

small thymus ( J:184080 )

thymus hypoplasia ( J:184080 )

enlarged spleen ( J:184080 )

abnormal T cell differentiation ( J:184080 )

• incomplete developmental block between DN3 and DN4

increased erythroid progenitor cell number ( J:184080 )

• in the spleen

decreased B cell number ( J:184080 )

• in the blood and spleen

increased effector memory CD4-positive, alpha-beta T cell number ( J:184080 )

decreased CD4-positive, alpha-beta T cell number ( J:184080 )

• in the blood and spleen

increased effector memory CD8-positive, alpha-beta T cell number ( J:184080 )

abnormal myeloid leukocyte morphology ( J:184080 )

• mice exhibit an increase in cells of myeloid origins (CD11c/Itgax+, CD11b/Itgam+ and Gr-1/Ly6g+) in the blood and spleen compared with wild-type mice

endocrine/exocrine glands

small thymus ( J:184080 )

thymus hypoplasia ( J:184080 )

growth/size/body

enlarged spleen ( J:184080 )