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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rgs2tm1.1Kjb
targeted mutation 1.1, Kendall J Blumer
MGI:5426401
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rgs2tm1.1Kjb/Rgs2tm1.1Kjb
Tg(Tek-cre/ERT2)1Arnd/? 		involves: 129X1/SvJ * C57BL/6 * DBA/2 MGI:5426418
cn2
 		Rgs2tm1.1Kjb/Rgs2tm1.1Kjb
X/Tg(Myh11-icre/ERT2)1Soff 		involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:5426419


Genotype
MGI:5426418
cn1
Allelic
Composition		 Rgs2tm1.1Kjb/Rgs2tm1.1Kjb
Tg(Tek-cre/ERT2)1Arnd/?
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs2tm1.1Kjb mutation (0 available); any Rgs2 mutation (21 available)
Tg(Tek-cre/ERT2)1Arnd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:184284 )
N
• phenylephrine constriction in mesenteric arteries after tamoxifen treatment is normal
• daytime arterial pressure is normal 1 week after tamoxifen treatment
• heart rate is normal
increased mean systemic arterial blood pressure ( J:184284 )
• dark phase pressure is increased somewhat by 9 days after tamoxifen treatment
decreased vasodilation ( J:184284 )
• vasodilation due to acetyl choline in mesenteric arteries after tamoxifen treatment is dramatically reduced
• sodium nitroprusside induced vasodilation after tamoxifen treatment is similar to controls
• luminal application of pertussis toxin restores acetyl choline vasodilation in mesenteric arteries

muscle
decreased vasodilation ( J:184284 )
• vasodilation due to acetyl choline in mesenteric arteries after tamoxifen treatment is dramatically reduced
• sodium nitroprusside induced vasodilation after tamoxifen treatment is similar to controls
• luminal application of pertussis toxin restores acetyl choline vasodilation in mesenteric arteries




Genotype
MGI:5426419
cn2
Allelic
Composition		 Rgs2tm1.1Kjb/Rgs2tm1.1Kjb
X/Tg(Myh11-icre/ERT2)1Soff
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs2tm1.1Kjb mutation (0 available); any Rgs2 mutation (21 available)
Tg(Myh11-icre/ERT2)1Soff mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:184284 )
N
• treatment with tamoxifen has an insignificant affect on either acetyl choline or sodium nitroprusside induced dilation of mesenteric arteries relative to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory