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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrc5tm1.1Ggaur
targeted mutation 1.1, Greta Guarda
MGI:5426421
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrc5tm1.1Ggaur/Nlrc5tm1.1Ggaur involves: BALB/cJ MGI:5426424


Genotype
MGI:5426424
hm1
Allelic
Composition		 Nlrc5tm1.1Ggaur/Nlrc5tm1.1Ggaur
Genetic
Background		 involves: BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc5tm1.1Ggaur mutation (0 available); any Nlrc5 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:184076 )
N
• bone marrow-derived macrophage cells exhibit normal stimulation of OT-I T cells
enlarged spleen ( J:184076 )
• at 34 to 36 weeks
decreased CD8-positive, alpha-beta T cell number ( J:184076 )
• slight decrease in percentage in spleen, lymph nodes and blood
abnormal T cell physiology ( J:184076 )
• T cells pulsed with SIINFEKL peptide and incubated with OT-I CD8+ effector T cells are less effectively killed by OT-I T cells compared with control cells

hematopoietic system
enlarged spleen ( J:184076 )
• at 34 to 36 weeks
decreased CD8-positive, alpha-beta T cell number ( J:184076 )
• slight decrease in percentage in spleen, lymph nodes and blood
abnormal T cell physiology ( J:184076 )
• T cells pulsed with SIINFEKL peptide and incubated with OT-I CD8+ effector T cells are less effectively killed by OT-I T cells compared with control cells

growth/size/body
enlarged spleen ( J:184076 )
• at 34 to 36 weeks




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory