All Phenotypes Fgfr3<tm2Llm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fgfr3^tm2Llm/Fgfr3⁺ Tg(Col1a1-cre)1Kry/0	involves: 129S2/SvPas * C57BL/6 * FVB	MGI:5426514
cn2	Fgfr3^tm2Llm/Fgfr3⁺ Tg(CMV-cre)1Ipc/?	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:5426512
cn3	Fgfr3^tm2Llm/Fgfr3⁺ Tg(Col2a1-cre)1Bhr/?	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:5426513

Allelic Composition	Fgfr3^tm2Llm/Fgfr3⁺ Tg(Col1a1-cre)1Kry/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3^tm2Llm mutation (0 available); any Fgfr3 mutation (54 available)
Tg(Col1a1-cre)1Kry mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:183772 )

N	• no obvious skeletal phenotype • normal growth plates • primary spongiosa is normal • normal trabecular bone

Allelic Composition	Fgfr3^tm2Llm/Fgfr3⁺ Tg(CMV-cre)1Ipc/?
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3^tm2Llm mutation (0 available); any Fgfr3 mutation (54 available)
Tg(CMV-cre)1Ipc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:183772 )

• severe dwarfism

skeleton

abnormal long bone morphology ( J:183772 )

decreased length of long bones ( J:183772 )

abnormal axial skeleton morphology ( J:183772 )

abnormal craniofacial bone morphology ( J:183772 )

• reduced width of skull

domed cranium ( J:183772 )

abnormal thoracic cage morphology ( J:183772 )

• narrow trunk

short ribs ( J:183772 )

abnormal bone structure ( J:183772 )

increased osteoclast cell number ( J:183772 )

• osteoclasts per bone area are increased

• osteoclast surface area/bone surface area is increased

abnormal trabecular bone morphology ( J:183772 )

• fewer subchondral trabeculae

• trabeculae only partially mineralized

• more abundant collagen deposition

• significantly lower bone volume/trabecular volume in distal metaphysis of the femur

abnormal skeleton development ( J:183772 )

abnormal long bone epiphyseal ossification zone morphology ( J:183772 )

• smaller hypertrophic mineralization zone

abnormal long bone epiphysis morphology ( J:183772 )

• reduced size of epiphysis

abnormal bone mineralization ( J:183772 )

• defect in mineralization of calcified cartilage and primary spongiosa

craniofacial

abnormal craniofacial bone morphology ( J:183772 )

• reduced width of skull

domed cranium ( J:183772 )

hematopoietic system

increased osteoclast cell number ( J:183772 )

• osteoclasts per bone area are increased

• osteoclast surface area/bone surface area is increased

immune system

increased osteoclast cell number ( J:183772 )

• osteoclasts per bone area are increased

• osteoclast surface area/bone surface area is increased

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:183772 )

• dwarfism

skeleton

abnormal long bone morphology ( J:183772 )

decreased length of long bones ( J:183772 )

abnormal axial skeleton morphology ( J:183772 )

abnormal craniofacial bone morphology ( J:183772 )

domed cranium ( J:183772 )

abnormal thoracic cage morphology ( J:183772 )

• narrow trunk

short ribs ( J:183772 )

abnormal bone structure ( J:183772 )

increased osteoclast cell number ( J:183772 )

• osteoclasts per bone area are increased

• osteoclast surface area/bone surface area is increased

abnormal trabecular bone morphology ( J:183772 )

• fewer subchondral trabeculae

• trabeculae only partially mineralized

• more abundant collagen deposition

• significantly lower bone volume/trabecular volume in distal metaphysis of the femur

abnormal skeleton development ( J:183772 )

abnormal long bone epiphyseal plate morphology ( J:183772 )

abnormal long bone epiphyseal ossification zone morphology ( J:183772 )

• smaller hypertrophic mineralization zone

abnormal long bone epiphyseal plate proliferative zone ( J:183772 )

• lack proliferative column organization

• proliferative zone reduced

decreased width of hypertrophic chondrocyte zone ( J:183772 )

• reduced hypertrophic zone

• small hypertrophic cells

abnormal long bone epiphysis morphology ( J:183772 )

• reduced size of epiphysis

abnormal bone mineralization ( J:183772 )

• defect in mineralization of calcified cartilage and primary spongiosa

delayed bone ossification ( J:183772 )

• delayed formation of secondary ossification centers

craniofacial

abnormal craniofacial bone morphology ( J:183772 )

domed cranium ( J:183772 )

hematopoietic system

increased osteoclast cell number ( J:183772 )

• osteoclasts per bone area are increased

• osteoclast surface area/bone surface area is increased

immune system

increased osteoclast cell number ( J:183772 )

• osteoclasts per bone area are increased

• osteoclast surface area/bone surface area is increased

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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