Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1.1(Maml1/EGFP)Hri}
• Allele Name: targeted mutation 1.1, Palle Serup
• Allele ID: MGI:5426507
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1.1(Maml1/EGFP)Hri/? Foxa2^tm3.1(icre)Heli/Foxa2^+	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5428767

Genotype
MGI:5428767

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1.1(Maml1/EGFP)Hri}/?; Foxa2^{tm3.1(icre)Heli}/Foxa2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreas development ( J:184814 )

• embryos show an increase in Neurog3+ve cells at E9.5; by E10.5, an increase in glucagon+ve cells is seen

• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos

• proximal-distal patterning is altered in the embryonic pancreas; at E15.5, Nkx6-1+ve, Ptf1a-ve cells are reduced in the proximal domain by 75% while Hnf1b and DBA+ve cells are reduced in number

• at E12.5, Nkx6-1+ve Ptf1a-ve are present, but reduced in numbers by 50% compared to controls along with a corresponding increase in Nkx6-1-ve Ptf1a+ve cells

abnormal pancreatic beta cell differentiation ( J:184814 )

• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos

cellular

abnormal pancreatic beta cell differentiation ( J:184814 )

• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos