All Phenotypes Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf
transgene insertion, Veronique Lefebvre
MGI:5426519

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sox9^tm1Gsr/Sox9^tm1Gsr Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0	involves: 129P2/OlaHsd * C57BL/6	MGI:5426540
cn2	Adgrg6^tm1Arte/Adgrg6^tm1Arte Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0	involves: 129S5/SvEvBrd	MGI:7266839
cn3	Prmt5^{tm2c(EUCOMM)Wtsi}/Prmt5^{tm2c(EUCOMM)Wtsi} Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0	involves: C57BL/6N	MGI:7277816

Allelic Composition	Sox9^tm1Gsr/Sox9^tm1Gsr Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9^tm1Gsr mutation (2 available); any Sox9 mutation (33 available)
Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal epiphyseal plate morphology ( J:183084 )

• with doxycycline treatment from E15.5 on, columnar zones are shortened in growth plates of mutants

chondrodystrophy ( J:183084 )

• with doxycycline treatment from E15.5 onward, severe dwarfism results

abnormal endochondral bone ossification ( J:183084 )

• endochondral bones stop elongating by E17.5 with doxycycline treatment from E15.5 onward

abnormal chondrocyte physiology ( J:183084 )

• chondrocytes lose ability to enlarge by E17.5 when doxycycline treatment takes place from E15.5 onward

• columnar cells stop proliferating at a rate 3 times greater than control cells with doxycycline treatment starting at E15.5; number of apoptotic cells in the columnar zone of growth plates is about 28 fold higher and about 5 times higher in the prehypertrophic zone of controls with 2 days of doxycycline treatment

Allelic Composition	Adgrg6^tm1Arte/Adgrg6^tm1Arte Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background	involves: 129S5/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg6^tm1Arte mutation (0 available); any Adgrg6 mutation (65 available)
Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal intervertebral disk morphology ( J:313834 )

• altered extracellular matrix component expression and endplate-oriented disk herniations at 8 months of age

scoliosis ( J:313834 )

• embryonic induction of recombinase induction resulted in scoliosis in 25% and 16.7% of mice with Cobb angles of 11 to 43 degrees at P20 and P180, respectively

Allelic Composition	Prmt5^{tm2c(EUCOMM)Wtsi}/Prmt5^{tm2c(EUCOMM)Wtsi} Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prmt5^{tm2c(EUCOMM)Wtsi} mutation (1 available); any Prmt5 mutation (45 available)
Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:283043 )

N	• no signs of scoliosis are seen following induction of recombinase expression at either 2 or 4 weeks of age

abnormal intervertebral disk morphology ( J:283043 )

• at 4 months of age, 3 months post induction of recombinase expression, there is a minor increase in acellular clefts at the midline of the endplate

• however, no gross signs of degenerative histopathology are seen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24