All Phenotypes Myl2<tm2.1Chen> MGI Mouse

premature death ( J:184548 )

• associated with dilated cardiomyopathy and heart failure

increased myocardial fiber size ( J:184548 )

• increased length but not width at 6 months and 6 weeks, respectively

• following transverse aortic constriction

thin interventricular septum ( J:184548 )

• at 10 months

increased heart weight ( J:184548 )

• increased ventricle weight

increased heart left ventricle size ( J:184548 )

• increased left ventricular internal dimension at end diastole at 6 and 10 months

• increased left ventricular internal dimension at end systole at 2, 6 and 10 months

• following transverse aortic constriction at 6 weeks

dilated heart ventricle ( J:184548 )

cardiac fibrosis ( J:184548 )

• in some mice

dilated cardiomyopathy ( J:184548 )

dystrophic cardiac calcinosis ( J:184548 )

• in some mice

decreased heart ventricle muscle contractility ( J:184548 )

• decreased ejection fraction at 2, 6 and 10 months

• at 6 weeks following transverse aortic constriction

abnormal myocardial fiber physiology ( J:184548 )

• at 6 weeks, mice exhibit accelerated twitch compared to in wild-type mice

• however, intracellular calcium transients are normal

increased response of heart to induced stress ( J:184548 )

• following transverse aortic constriction, young mice exhibit increased left ventricle weight without a change in chamber wall thickness, reduced fractional shortening, increased left ventricular internal dimensions at diastole and systole, and increased cardiomyocyte length without a change in width compared with wild-type mice

congestive heart failure ( J:184548 )