Phenotypes associated with this allele

• Allele Symbol: Smarcc1^tm2.1Rhs
• Allele Name: targeted mutation 2.1, Rho H Seong
• Allele ID: MGI:5426542
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Smarcc1^tm2.1Rhs/Smarcc1^tm2.1Rhs Tg(Mx1-cre)1Cgn/0	involves: BALB/c * C57BL/6 * CBA	MGI:5426682

Genotype
MGI:5426682

cn1

• Allelic Composition: Smarcc1^tm2.1Rhs/Smarcc1^tm2.1Rhs; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: BALB/c * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell apoptosis ( J:184060 )

• of pro-B cells from pIpC-treated mice exposed to IL7

decreased B cell proliferation ( J:184060 )

• of pro-B cells from pIpC-treated mice exposed to IL7

abnormal immature B cell morphology ( J:184060 )

• reduced frequency in pIpC-treated mice

abnormal immunoglobulin heavy chain V(D)J recombination ( J:184060 )

• reduced in pro-B cells

abnormal pro-B cell morphology ( J:184060 )

• lower frequency of early (fraction B) and late (fraction C) pro-B cell in pIpC-treated mice

• higher frequency of pre-pro-B cells in pIpC-treated mice

• however, the number of pre-pro-B cells is normal

decreased pro-B cell number ( J:184060 )

• reduced numbers in pIpC-treated mice

decreased early pro-B cell number ( J:184060 )

• severely decreased numbers in pIpC-treated mice

decreased late pro-B cell number ( J:184060 )

• severely decreased numbers in pIpC-treated mice

arrested B cell differentiation ( J:184060 )

• at the early stage of B-lineage cells in the bone marrow of pIpC-treated mice

decreased B cell number ( J:184060 )

• in the bone marrow and spleen of pIpC-treated mice

decreased follicular B cell number ( J:184060 )

• by half in pIpC-treated mice

abnormal pre-B cell morphology ( J:184060 )

• reduced frequency in pIpC-treated mice

cellular

increased B cell apoptosis ( J:184060 )

• of pro-B cells from pIpC-treated mice exposed to IL7

decreased B cell proliferation ( J:184060 )

• of pro-B cells from pIpC-treated mice exposed to IL7

hematopoietic system

increased B cell apoptosis ( J:184060 )

• of pro-B cells from pIpC-treated mice exposed to IL7

decreased B cell proliferation ( J:184060 )

• of pro-B cells from pIpC-treated mice exposed to IL7

abnormal immature B cell morphology ( J:184060 )

• reduced frequency in pIpC-treated mice

abnormal immunoglobulin heavy chain V(D)J recombination ( J:184060 )

• reduced in pro-B cells

abnormal pro-B cell morphology ( J:184060 )

• however, the number of pre-pro-B cells is normal

• lower frequency of early (fraction B) and late (fraction C) pro-B cell in pIpC-treated mice

• higher frequency of pre-pro-B cells in pIpC-treated mice

decreased pro-B cell number ( J:184060 )

• reduced numbers in pIpC-treated mice

decreased early pro-B cell number ( J:184060 )

• severely decreased numbers in pIpC-treated mice

decreased late pro-B cell number ( J:184060 )

• severely decreased numbers in pIpC-treated mice

arrested B cell differentiation ( J:184060 )

• at the early stage of B-lineage cells in the bone marrow of pIpC-treated mice

abnormal bone marrow cell morphology/development ( J:184060 )

• pIpC-treated mice exhibit a mild decrease in lymphoid-primed multipotent progenitors compared with control mice

abnormal common lymphocyte progenitor cell morphology ( J:184060 )

• pIpC-treated mice exhibit a reduction in common lymphoid progenitors highly expressing AA4.1/Cd93 compared with control mice

decreased B cell number ( J:184060 )

• in the bone marrow and spleen of pIpC-treated mice

decreased follicular B cell number ( J:184060 )

• by half in pIpC-treated mice

abnormal pre-B cell morphology ( J:184060 )

• reduced frequency in pIpC-treated mice