All Phenotypes Oma1<tm1Otin> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oma1^tm1Otin/Oma1^tm1Otin	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr	MGI:5426691
cx2	Chchd10^em3Dpn/Chchd10^em3Dpn Oma1^tm1Otin/Oma1^tm1Otin	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl	MGI:7579309
cx3	Chchd10^em3Dpn/Chchd10^em3Dpn Oma1^tm1Otin/Oma1⁺	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl	MGI:7579310

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased fatty acid beta-oxidation ( J:184716 )

• mice fed standard chow exhibit decreased fatty acid beta-oxidation in brown adipose tissue compared with wild-type mice

• mice fed a high fat diet exhibit decreased fatty acid beta-oxidation in brown adipose tissue and liver compared with wild-type mice

increased susceptibility to diet-induced obesity ( J:184716 )

• at 8 weeks when fed a high fat diet

abnormal blood homeostasis ( J:184716 )

increased circulating leptin level ( J:184716 )

• when fed a high fat diet

increased circulating triglyceride level ( J:184716 )

• when fed a high fat diet

increased circulating alanine transaminase level ( J:184716 )

• when fed a high fat diet

increased circulating aspartate transaminase level ( J:184716 )

• when fed a high fat diet

decreased body temperature ( J:184716 )

• when cold exposed

abnormal circadian temperature homeostasis ( J:184716 )

• mice fed standard chow fail to exhibit an increase in body temperature during the night unlike wild-type mice

abnormal gas homeostasis ( J:184716 )

decreased carbon dioxide production ( J:184716 )

• when fed standard chow

decreased oxygen consumption ( J:184716 )

• when fed standard chow

abnormal glucose homeostasis ( J:184716 )

decreased circulating insulin level ( J:184716 )

• when fed standard chow

impaired glucose tolerance ( J:184716 )

• when fed a high fat diet

increased insulin sensitivity ( J:184716 )

• when fed standard chow but not a high fat diet

decreased basal metabolism ( J:184716 )

• mice fed standard chow exhibit decreased heat production compared with control mice

cellular

abnormal mitochondrial morphology ( J:184716 )

• prior to and after treatment with CCCP, mouse embryonic fibroblasts exhibit alterations in mitochondria morphology with lower fragmentation compared with wild-type cells

abnormal fat cell mitochondrial morphology ( J:184716 )

• mitochondria of brown adipose tissue from cold-exposed mice fed a high fat diet fail to exhibit an increase in mitochondria area unlike wild-type mice

• however, mice do not exhibit a change in the number of mitochondria

decreased mitochondrial DNA content ( J:184716 )

• in mouse embryonic fibroblasts

increased mitochondrial size ( J:184716 )

• in brown adipose tissue of mice fed a high fat diet

abnormal cell physiology ( J:184716 )

• mouse embryonic fibroblasts treated with CCCP, straurosporine or oligomycin exhibit altered OPA1 processing compared with wild-type cells

decreased cellular sensitivity to alkylating agents ( J:184716 )

• in straurosporine treated mouse embryonic fibroblasts

decreased fatty acid beta-oxidation ( J:184716 )

• mice fed standard chow exhibit decreased fatty acid beta-oxidation in brown adipose tissue compared with wild-type mice

• mice fed a high fat diet exhibit decreased fatty acid beta-oxidation in brown adipose tissue and liver compared with wild-type mice

adipose tissue

abnormal fat cell mitochondrial morphology ( J:184716 )

• mitochondria of brown adipose tissue from cold-exposed mice fed a high fat diet fail to exhibit an increase in mitochondria area unlike wild-type mice

• however, mice do not exhibit a change in the number of mitochondria

increased white fat cell size ( J:184716 )

• in gonadal and subcutaneous fat pads when mice are fed a high fat diet

increased gonadal fat pad weight ( J:184716 )

• when fed a high fat diet

abnormal mesenteric fat pad morphology ( J:184716 )

• granuloma-like lesions with necrosis foci in intestinal mesenteric fat when mice are fed a high fat diet

abnormal brown adipose tissue thermogenesis ( J:184716 )

• cold-exposed mice fail to exhibit a decrease in brown adipose tissue droplet size unlike wild-type mice

growth/size/body

increased body weight ( J:184716 )

• when fed standard chow

• at 8 weeks when fed a high fat diet

increased susceptibility to diet-induced obesity ( J:184716 )

• at 8 weeks when fed a high fat diet

liver/biliary system

hepatic steatosis ( J:184716 )

• when fed standard chow or a high fat diet

immune system

granulomatous inflammation ( J:184716 )

• granuloma-like lesions with necrosis foci in intestinal mesenteric fat when mice are fed a high fat diet

Allelic Composition	Chchd10^em3Dpn/Chchd10^em3Dpn Oma1^tm1Otin/Oma1^tm1Otin
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chchd10^em3Dpn mutation (0 available); any Chchd10 mutation (17 available)
Oma1^tm1Otin mutation (0 available); any Oma1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:344465 )

• neonatal lethality with few mice surviving to weaning

postnatal lethality, incomplete penetrance ( J:344465 )

• most pups die between P5 and P8, with the few survivors dying by 15 weeks of age

growth/size/body

enlarged heart ( J:344465 )

• mice that survive to 15 weeks of age have enlarged hearts

decreased body size ( J:344465 )

• mice that survive to 15 weeks of age exhibit decreased body size

decreased body weight ( J:344465 )

• body weight is lower at P5 but not at P1

cardiovascular system

enlarged heart ( J:344465 )

• mice that survive to 15 weeks of age have enlarged hearts

cellular

abnormal mitochondrial crista morphology ( J:344465 )

• heart mitochondria exhibit inclusions

abnormal mitochondrial shape ( J:344465 )

• surviving mice exhibit heart mitochondria that are longer but tend to have decreased caliber and thus smaller in volume

dilated mitochondrion ( J:344465 )

• megamitochondria, massively swollen mitochondria with lighter matrix density, are seen in hearts of 14-week-old mice

Allelic Composition	Chchd10^em3Dpn/Chchd10^em3Dpn Oma1^tm1Otin/Oma1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle fiber mitochondrial morphology ( J:344465 )

• hearts show mitochondrial fragmentation, megamitochondria, and inclusions due to reshaping of the inner membrane

cellular

abnormal mitochondrial morphology ( J:344465 )

• mice exhibit smaller heart mitochondria, reflecting mitochondrial fragmentation

abnormal mitochondrial crista morphology ( J:344465 )

• heart mitochondria exhibit inclusions due to reshaping of the inner membrane

abnormal muscle fiber mitochondrial morphology ( J:344465 )

• hearts show mitochondrial fragmentation, megamitochondria, and inclusions due to reshaping of the inner membrane

dilated mitochondrion ( J:344465 )

• megamitochondria, massively swollen mitochondria with lighter matrix density, are seen in hearts of 14-week-old mice

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