Phenotypes associated with this allele

• Allele Symbol: Abcb6^tm1Jsch
• Allele Name: targeted mutation 1, John D Schuetz
• Allele ID: MGI:5426703
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abcb6^tm1Jsch/Abcb6^tm1Jsch	involves: 129	MGI:5426704

Genotype
MGI:5426704

hm1

• Allelic Composition: Abcb6^tm1Jsch/Abcb6^tm1Jsch
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:184574 )

• increased mortality at 3 - 7 days after treatment with phenylhydrazine (50 mg/kg)

lethality, incomplete penetrance ( J:184574 )

• about 10% fewer homozygotes are found

cellular

abnormal mitochondrial physiology ( J:184574 )

• absence of ATP-dependent transport of Coproporphyrin III

hematopoietic system

abnormal stress erythropoiesis ( J:184574 )

• impairment in stress erythropoiesis with decreased mean hematocrit, increased reticulocyte numbers, prolonged anemia, and reduced mean corpuscular volumes after treatment with phenylhydrazine (50 mg/kg)

• following phenylhydrazine treatment surviving mice show a longer time to maximal recovery

abnormal erythrocyte physiology ( J:184574 )

• elevated protoporphyrin IX levels

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:184574 )

• increased mortality at 3 - 7 days after treatment with phenylhydrazine (50 mg/kg)

increased physiological sensitivity to xenobiotic ( J:184574 )

• impairment in stress erythropoiesis with decreased mean hematocrit, increased reticulocyte numbers, prolonged anemia, and reduced mean corpuscular volumes after treatment with phenylhydrazine (50 mg/kg)

• following phenylhydrazine treatment surviving mice show a longer time to maximal recovery