All Phenotypes Maged1<tm1Tnab> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Maged1^tm1Tnab
targeted mutation 1, Toshitaka Nabeshima
MGI:5426784

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Maged1^tm1Tnab/Maged1^tm1Tnab	B6.129P2-Maged1^tm1Tnab	MGI:5426791
ht2	Maged1^tm1Tnab/Maged1⁺	B6.129P2-Maged1^tm1Tnab	MGI:5426793
ot3	Maged1^tm1Tnab/Y	B6.129P2-Maged1^tm1Tnab	MGI:5426790

Allelic Composition	Maged1^tm1Tnab/Maged1^tm1Tnab
Genetic Background	B6.129P2-Maged1^tm1Tnab

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maged1^tm1Tnab mutation (1 available); any Maged1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:183858 )

N	• mice exhibit normal anxiety-like behavior, motor coordination and learning, and cognitive functions

decreased exploration in new environment ( J:183858 )

anhedonia ( J:183858 )

• in a sucrose preference test

behavioral despair ( J:183858 )

• in a forced swim test, mice spend longer time in an immobile posture compared with wild-type mice

• however, acute and chronic administration of sertraline or imipramine decreases the amount of time spent in immobile posture

decreased locomotor activity ( J:183858 )

• in the home cage and a novel environment

• however, acute and chronic treatment with sertraline or chronic imipramine treatment increases locomotor activity

social withdrawal ( J:183858 )

• mice exhibit social withdrawal in a social interaction test compared with wild-type mice

• however, acute and chronic treatment with sertraline or chronic imipramine treatment attenuates decreased social interaction

homeostasis/metabolism

abnormal serotonin level ( J:183858 )

• serotonin turnover is reduced in the hippocampus and amygdala compared to in wild-type mice

• potassium stimulation fails to increase serotonin levels in the prefrontal cortex and hippocampus unlike in wild-type mice

decreased serotonin level ( J:183858 )

• in the prefrontal cortex

• decreased 5-HIAA in the amygdala

increased serotonin level ( J:183858 )

• in the hippocampus

Allelic Composition	Maged1^tm1Tnab/Maged1⁺
Genetic Background	B6.129P2-Maged1^tm1Tnab

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maged1^tm1Tnab mutation (1 available); any Maged1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased exploration in new environment ( J:183858 )

behavioral despair ( J:183858 )

• in a forced swim test, mice spend longer time in an immobile posture compared with wild-type mice

decreased locomotor activity ( J:183858 )

• in a novel environment

social withdrawal ( J:183858 )

Allelic Composition	Maged1^tm1Tnab/Y
Genetic Background	B6.129P2-Maged1^tm1Tnab

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maged1^tm1Tnab mutation (1 available); any Maged1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:183858 )

N	• mice exhibit normal anxiety-like behavior, motor coordination and learning, and cognitive functions

decreased exploration in new environment ( J:183858 )

anhedonia ( J:183858 )

• in a sucrose preference test

behavioral despair ( J:183858 )

• in a forced swim test, mice spend longer time in an immobile posture compared with wild-type mice

• however, acute and chronic administration of sertraline or imipramine decreases the amount of time spent in immobile posture

decreased locomotor activity ( J:183858 )

• in the home cage and a novel environment

• however, acute and chronic treatment with sertraline or chronic imipramine treatment increases locomotor activity

social withdrawal ( J:183858 )

• mice exhibit social withdrawal in a social interaction test compared with wild-type mice

• however, acute and chronic treatment with sertraline or chronic imipramine treatment attenuates decreased social interaction

homeostasis/metabolism

abnormal serotonin level ( J:183858 )

• serotonin turnover is reduced in the hippocampus and amygdala compared to in wild-type mice

• potassium stimulation fails to increase serotonin levels in the prefrontal cortex and hippocampus unlike in wild-type mice

decreased serotonin level ( J:183858 )

• in the prefrontal cortex

• decreased 5-HIAA in the amygdala

increased serotonin level ( J:183858 )

• in the hippocampus

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