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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lama1tm1.1Arhi
targeted mutation 1.1, Eri Arikawa-Hirasawa
MGI:5426811
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lama1tm1.1Arhi/Lama1tm1.1Arhi involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5426830
ht2
Lama1tm1.1Arhi/Lama1tm1.2Arhi involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5426831
cn3
Lama1tm1.1Arhi/Lama1tm1.2Arhi
Edil3Tg(Sox2-cre)1Amc/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5426832


Genotype
MGI:5426830
hm1
Allelic
Composition
Lama1tm1.1Arhi/Lama1tm1.1Arhi
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama1tm1.1Arhi mutation (0 available); any Lama1 mutation (186 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are fertile and phenotypically normal




Genotype
MGI:5426831
ht2
Allelic
Composition
Lama1tm1.1Arhi/Lama1tm1.2Arhi
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama1tm1.1Arhi mutation (0 available); any Lama1 mutation (186 available)
Lama1tm1.2Arhi mutation (0 available); any Lama1 mutation (186 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice develop normally




Genotype
MGI:5426832
cn3
Allelic
Composition
Lama1tm1.1Arhi/Lama1tm1.2Arhi
Edil3Tg(Sox2-cre)1Amc/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Lama1tm1.1Arhi mutation (0 available); any Lama1 mutation (186 available)
Lama1tm1.2Arhi mutation (0 available); any Lama1 mutation (186 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice complete gestation and survive postnatally

behavior/neurological
• shorter latency to fall in a rotarod test

nervous system
• decreased depth of folia
• aggregations of granule cells on cerebellar surface along the line of fusion between adjacent folia
• Purkinje cell layer is distorted
• some Purkinje cells are not located in Purkinje cell layer
• fibers are short with fragmented endfeet
• dendritic tree of Purkinje cells is reduced
• fewer proliferating granule cell precursors from birth to 10 days of age
• migration of granule cells from external to internal layer is not observed
• superior colliculus is exposed on the surface of the brain
• pial basement membrane is irregular
• density of glial cells is reduced

cellular





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory