Phenotypes associated with this allele

• Allele Symbol: Lama1^tm1.2Arhi
• Allele Name: targeted mutation 1.2, Eri Arikawa-Hirasawa
• Allele ID: MGI:5426812
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lama1^tm1.2Arhi/Lama1^tm1.2Arhi	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5426829
ht2	Lama1^tm1.1Arhi/Lama1^tm1.2Arhi	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5426831
cn3	Lama1^tm1.1Arhi/Lama1^tm1.2Arhi Edil3^Tg(Sox2-cre)1Amc/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5426832

Genotype
MGI:5426829

hm1

• Allelic Composition: Lama1^tm1.2Arhi/Lama1^tm1.2Arhi
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:184432 )

• homozygotes die by E7

embryo

absent Reichert's membrane ( J:184432 )

Genotype
MGI:5426831

ht2

• Allelic Composition: Lama1^tm1.1Arhi/Lama1^tm1.2Arhi
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:184432 )

• mice develop normally

Genotype
MGI:5426832

cn3

• Allelic Composition: Lama1^tm1.1Arhi/Lama1^tm1.2Arhi; Edil3^{Tg(Sox2-cre)1Amc}/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

mortality/aging ( J:184432 )

N • mice complete gestation and survive postnatally

behavior/neurological

limb grasping ( J:184432 )

impaired coordination ( J:184432 )

• shorter latency to fall in a rotarod test

short stride length ( J:184432 )

nervous system

abnormal radial glial cell morphology ( J:184432 )

• fibers are short

abnormal cerebellum morphology ( J:184432 )

abnormal cerebellar foliation ( J:184432 )

• decreased depth of folia

• aggregations of granule cells on cerebellar surface along the line of fusion between adjacent folia

abnormal cerebellar Purkinje cell layer ( J:184432 )

• Purkinje cell layer is distorted

• some Purkinje cells are not located in Purkinje cell layer

abnormal Bergmann glial cell morphology ( J:184432 )

• fibers are short with fragmented endfeet

abnormal Purkinje cell dendrite morphology ( J:184432 )

• dendritic tree of Purkinje cells is reduced

abnormal cerebellar granule layer morphology ( J:184432 )

• fewer proliferating granule cell precursors from birth to 10 days of age

• migration of granule cells from external to internal layer is not observed

small cerebellum ( J:184432 )

• superior colliculus is exposed on the surface of the brain

abnormal brain meninges morphology ( J:184432 )

• meninges are thin

abnormal brain pia mater morphology ( J:184432 )

• pial basement membrane is irregular

• density of glial cells is reduced

cellular

abnormal radial glial cell morphology ( J:184432 )

• fibers are short