Phenotypes associated with this allele

• Allele Symbol: Tpx2^{Gt(D028B03)1.1Wrst}
• Allele Name: gene trap D028B03, 1.1, German Gene Trap Consortium
• Allele ID: MGI:5426862
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tpx2^Gt(D028B03)1.1Wrst/Tpx2^Gt(D028B03)1.1Wrst	involves: 129S2/SvPas * C57BL/6J	MGI:5426867

Genotype
MGI:5426867

cn1

• Allelic Composition: Tpx2^{Gt(D028B03)1.1Wrst}/Tpx2^{Gt(D028B03)1.1Wrst}
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell nucleus morphology ( J:184948 )

• mouse embryonic fibroblasts transfected with cre-expressing adenovirus and serum starved exhibit multiple nuclei or micronuclei unlike control cells

polyploidy ( J:184948 )

• mouse embryonic fibroblasts transfected with cre-expressing adenovirus and serum starved exhibit tetraploidy unlike control cells

abnormal mitosis ( J:184948 )

• mouse embryonic fibroblasts transfected with cre-expressing adenovirus exhibit longer mitosis compared with control cells

abnormal mitotic spindle assembly checkpoint ( J:184948 )

• mouse embryonic fibroblasts transfected with cre-expressing adenovirus exhibit impaired spindle assembly checkpoint with delayed mitotic exit compared with control cells

decreased cell proliferation ( J:184948 )

• of mouse embryonic fibroblasts transfected with cre-expressing adenovirus