Phenotypes associated with this allele

• Allele Symbol: Rgs7^tm1Cjch
• Allele Name: targeted mutation 1, Ching-Kang Chen
• Allele ID: MGI:5426905
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rgs7^tm1Cjch/Rgs7^tm1Cjch	involves: C57BL/6	MGI:5426906
cx2	Rgs11^tm1Lex/Rgs11^tm1Lex Rgs7^tm1Cjch/Rgs7^tm1Cjch	involves: 129S5/SvEvBrd * C57BL/6	MGI:5426907

Genotype
MGI:5426906

hm1

• Allelic Composition: Rgs7^tm1Cjch/Rgs7^tm1Cjch
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:184922 )

N • normal viability

reproductive system

reproductive system phenotype ( J:184922 )

N • normal fertility

vision/eye

delayed eyelid opening ( J:184922 )

• by 24 to 48 hours

abnormal eye electrophysiology ( J:184922 )

• prolonged b-wave implicit time at P16 and less pronounced at P30

• however, b-wave is normal at 2 months

growth/size/body

decreased body size ( J:184922 )

• at P3

slow postnatal weight gain ( J:184922 )

• no weight gain P15 to P19

Genotype
MGI:5426907

cx2

• Allelic Composition: Rgs11^tm1Lex/Rgs11^tm1Lex; Rgs7^tm1Cjch/Rgs7^tm1Cjch
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Rgs7^tm1Cjch/Rgs7^tm1Cjch Rgs11^tm1Lex/Rgs11^tm1Lex mice have no ERG b-waves and contain ultrastructural defects in the retinal outer plexiform layer

mortality/aging

mortality/aging ( J:184922 )

N • normal viability

reproductive system

reproductive system phenotype ( J:184922 )

N • normal fertility

vision/eye

abnormal retina outer plexiform layer morphology ( J:184922 )

• fewer triads per spherule compared to in wild-type mice

• fewer spherules with ribbons compared to in wild-type mice

abnormal cone electrophysiology ( J:184922 )

• absent b-wave under scotopic and photopic conditions

abnormal rod electrophysiology ( J:184922 )

• absent b-wave under scotopic and photopic conditions