Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm47(HTT)Arte}
• Allele Name: targeted mutation 47, TaconicArtemis
• Allele ID: MGI:5426927
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gt(ROSA)26Sor^tm47(HTT)Arte/Gt(ROSA)26Sor^+	Not Specified	MGI:5432175

Genotype
MGI:5432175

ht1

• Allelic Composition: Gt(ROSA)26Sor^{tm47(HTT)Arte}/Gt(ROSA)26Sor⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:243843 )

• mice live for a median period of 277 days

behavior/neurological

impaired coordination ( J:243843 )

• mice exhibit impaired rotarod performance at 6 months of age

decreased vertical activity ( J:243843 )

• mice show reduced rearing at 4 and 5 months of age

decreased locomotor activity ( J:243843 )

• mice show reduced number of floor plan moves in the open field at 5 months of age

nervous system

nervous system inclusion bodies ( J:243843 )

• striatum and cortex exhibit aggregation of HTT at 4 months of age indicating neuronal pathology