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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Casp6tm1.2Xen
targeted mutation 1.2, Taconic Biosciences
MGI:5426933
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Casp6tm1.2Xen/Casp6tm1.2Xen FVB.B6NTac-Casp6tm1.2Xen MGI:5315761
ht2
 		Casp6tm1.2Xen/Casp6+ FVB.B6NTac-Casp6tm1.2Xen MGI:5315762


Genotype
MGI:5315761
hm1
Allelic
Composition		 Casp6tm1.2Xen/Casp6tm1.2Xen
Genetic
Background		 FVB.B6NTac-Casp6tm1.2Xen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp6tm1.2Xen mutation (0 available); any Casp6 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:181879 )
N
• at 3 months, mice exhibit normal cortex volume, striatal volume, neuronal striatal counts, brain weight and cerebellum weight
• at 8 months, mice exhibit normal brain and cerebellum weight
increased striatum size ( J:181879 )
• increased striatal volume at 8 months
abnormal cerebral cortex morphology ( J:181879 )
• increased cortical volume at 8 months
abnormal nervous system physiology ( J:181879 )
• after NFG withdrawal, neurons are protected from axonal degeneration compared with wild-type cells
• septal cholinergic neurons are protected from myelin-induced degeneration compared with wild-type cells
decreased susceptibility to neuronal excitotoxicity ( J:181879 )
• medium spiny neurons are protected from NMDA-mediated excitotoxicity compared with wild-type cells

behavior/neurological
abnormal response to novel object ( J:181879 )
• at 12 months, mice exhibit decreased novel object preference compared with wild-type mice
decreased locomotor activity ( J:181879 )
• in an open field

cellular
decreased susceptibility to neuronal excitotoxicity ( J:181879 )
• medium spiny neurons are protected from NMDA-mediated excitotoxicity compared with wild-type cells

homeostasis/metabolism
decreased susceptibility to neuronal excitotoxicity ( J:181879 )
• medium spiny neurons are protected from NMDA-mediated excitotoxicity compared with wild-type cells




Genotype
MGI:5315762
ht2
Allelic
Composition		 Casp6tm1.2Xen/Casp6+
Genetic
Background		 FVB.B6NTac-Casp6tm1.2Xen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp6tm1.2Xen mutation (0 available); any Casp6 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased susceptibility to neuronal excitotoxicity ( J:181879 )
• medium spiny neurons are protected from NMDA-mediated excitotoxicity compared with wild-type cells
increased striatum size ( J:181879 )
• increased striatal volume at 8 months, not as much as in homozygotes
abnormal cerebral cortex morphology ( J:181879 )
• increased cortical volume at 8 months, not as much as in homozygotes

homeostasis/metabolism
decreased susceptibility to neuronal excitotoxicity ( J:181879 )
• medium spiny neurons are protected from NMDA-mediated excitotoxicity compared with wild-type cells

cellular
decreased susceptibility to neuronal excitotoxicity ( J:181879 )
• medium spiny neurons are protected from NMDA-mediated excitotoxicity compared with wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory