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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Soat2tm1.1Llr
targeted mutation 1.1, Lawrence L Rudel
MGI:5426949
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Soat2tm1.1Llr/Soat2tm1.1Llr involves: 129S/SvEv MGI:5426954
cn2
 		Soat2tm1.1Llr/Soat2tm1.1Llr
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA MGI:5426955
cn3
 		Soat2tm1.1Llr/Soat2tm1.1Llr
Tg(Vil1-cre)997Gum/0 		involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL MGI:5426956


Genotype
MGI:5426954
hm1
Allelic
Composition		 Soat2tm1.1Llr/Soat2tm1.1Llr
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Soat2tm1.1Llr mutation (1 available); any Soat2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:184908 )
N
• mice exhibit normal cholesterol absorption




Genotype
MGI:5426955
cn2
Allelic
Composition		 Soat2tm1.1Llr/Soat2tm1.1Llr
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Soat2tm1.1Llr mutation (1 available); any Soat2 mutation (40 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating cholesterol level ( J:184908 )
• in mice fed a 0.05% cholesterol diet
decreased circulating LDL cholesterol level ( J:184908 )
• in mice fed a 0.05% cholesterol diet
decreased circulating VLDL cholesterol level ( J:184908 )
• in mice fed a 0.1% or 0.5% dietary cholesterol
increased circulating triglyceride level ( J:184908 )
• regardless of dietary cholesterol percentage
decreased liver cholesterol level ( J:184908 )
• total cholesterol and cholesteryl ester regardless of dietary cholesterol percentage
• free cholesterol when fed a 0.5% cholesterol diet
decreased liver triglyceride level ( J:184908 )
• when fed a 0.5% cholesterol diet

liver/biliary system
decreased liver cholesterol level ( J:184908 )
• total cholesterol and cholesteryl ester regardless of dietary cholesterol percentage
• free cholesterol when fed a 0.5% cholesterol diet
decreased liver triglyceride level ( J:184908 )
• when fed a 0.5% cholesterol diet

digestive/alimentary system
digestive/alimentary phenotype ( J:184908 )
N
• mice exhibit normal cholesterol absorption




Genotype
MGI:5426956
cn3
Allelic
Composition		 Soat2tm1.1Llr/Soat2tm1.1Llr
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Soat2tm1.1Llr mutation (1 available); any Soat2 mutation (40 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased intestinal cholesterol absorption ( J:184908 )
• regardless of dietary cholesterol percentage, mice exhibit decreased cholesterol absorption compared with control mice
• when fed 0.05% or 0.1% dietary cholesterol, mice exhibit increased fecal cholesterol loss compared with control mice
increased circulating triglyceride level ( J:184908 )
• in mice fed a 0.05% or 0.5% dietary cholesterol
decreased cholesterol level ( J:184908 )
• decreased biliary cholesterol regardless of dietary cholesterol percentage
• decreased cholesteryl ester in intestinal enterocytes regardless of dietary cholesterol percentage
decreased circulating cholesterol level ( J:184908 )
• in mice fed a 0.05% or 0.5% dietary cholesterol
decreased circulating VLDL cholesterol level ( J:184908 )
• in mice fed a 0.1% or 0.5% dietary cholesterol
decreased liver cholesterol level ( J:184908 )
• total cholesterol and cholesteryl ester regardless of dietary cholesterol percentage
• free cholesterol when fed a 0.5% cholesterol diet
increased cholesterol level ( J:184908 )
• total and free cholesterol are increased in intestinal enterocytes of mice fed a 0.5% cholesterol diet
decreased liver triglyceride level ( J:184908 )
• when fed a 0.5% cholesterol diet

digestive/alimentary system
decreased intestinal cholesterol absorption ( J:184908 )
• regardless of dietary cholesterol percentage, mice exhibit decreased cholesterol absorption compared with control mice
• when fed 0.05% or 0.1% dietary cholesterol, mice exhibit increased fecal cholesterol loss compared with control mice

liver/biliary system
decreased liver cholesterol level ( J:184908 )
• total cholesterol and cholesteryl ester regardless of dietary cholesterol percentage
• free cholesterol when fed a 0.5% cholesterol diet
decreased liver triglyceride level ( J:184908 )
• when fed a 0.5% cholesterol diet




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory