Analysis Tools
integument
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• attachment to a secreted cell matrix is reduced in vitro
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• keratinocytes migrate more slowly in vitro and migration is not altered by removal to TGFB from the medium
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• some mice develop spontaneous skin erosions around their face and neck and across the entire body
• Background Sensitivity: erosions occur in about 25% of mice on a CD-1 background and 40% of mice on a C57BL/6 background
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homeostasis/metabolism
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• wounds remain open at 12 days post injury (8-mm full-thickness wound) unlike in wild-type controls
• closure is also delayed after epidermal abrasion wounding and corneal wounding
• sustained presence of inflammatory cells following wounding
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growth/size/body
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• about 10% of pups are visibly smaller than wild-type littermates
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reproductive system
immune system
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• the number of phagocytosing macrophage is reduced compared to in wild-type mice
• however, macrophage exhibit normal cell viability
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vision/eye
hematopoietic system
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• the number of phagocytosing macrophage is reduced compared to in wild-type mice
• however, macrophage exhibit normal cell viability
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cellular
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• attachment to a secreted cell matrix is reduced in vitro
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• keratinocytes migrate more slowly in vitro and migration is not altered by removal to TGFB from the medium
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• the number of phagocytosing macrophage is reduced compared to in wild-type mice
• however, macrophage exhibit normal cell viability
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