Phenotypes associated with this allele

• Allele Symbol: Cdh1^tm2.1Mpst
• Allele Name: targeted mutation 2.1, Marc P Stemmler
• Allele ID: MGI:5426968
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdh1^tm2.1Mpst/Cdh1^tm2.1Mpst	involves: C57BL/6 * FVB/N	MGI:5426970

Genotype
MGI:5426970

hm1

• Allelic Composition: Cdh1^tm2.1Mpst/Cdh1^tm2.1Mpst
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cdh1^tm2.1Mpst/Cdh1^tm2.1Mpst embryos cannot form a trophectoderm layer

embryo

increased trophectoderm apoptosis ( J:183847 )

• increased apoptosis of trophectoderm cells

absent blastocoele ( J:183847 )

• however, blastocyst formation can be rescued by blocking programmed cell death or activating insulin-like growth factor I receptor signaling

absent trophectoderm ( J:183847 )

• mice fail to form an intact trophectoderm layer

cellular

increased trophectoderm apoptosis ( J:183847 )

• increased apoptosis of trophectoderm cells