All Phenotypes Smarca1<tm1.1Pick> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smarca1^tm1.1Pick/Smarca1^tm1.1Pick	involves: 129S4/SvJae * CD-1	MGI:5427350
cx2	Smarca1^tm1.1Pick/Y Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129P2/OlaHsd * 129S4/SvJae * CD-1	MGI:5427352
ot3	Smarca1^tm1.1Pick/Y	involves: 129S4/SvJae * CD-1	MGI:5427351

Allelic Composition	Smarca1^tm1.1Pick/Smarca1^tm1.1Pick
Genetic Background	involves: 129S4/SvJae * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca1^tm1.1Pick mutation (0 available); any Smarca1 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:183998 )

• enhanced self-renewal in neuronal precursors at E13.5

abnormal neuronal precursor proliferation ( J:183998 )

• increase in the proportion of mitotic cells in the ventricular zone at E15.5

• increase in the number of BrdU positive cells in the neocortex at E13.5 and E15.5

• increase in the number of proliferating apical and intermediate/basal progenitor cells and in intermediate/basal progenitor cells in the neocortex at E13.5 and E15.5, respectively

• significantly shorter S phase in neuronal progenitors at E15.5

abnormal telencephalon development ( J:183998 )

• expression analysis indicates potential changes to cell fate within layers V/VI at E15.5 and layer V at E17.5

increased cortical ventricular zone cell density ( J:183998 )

• increased cell density at E15.5

increased brain weight ( J:183998 )

• increase in brain:body mass ratio resulting from an increase in brain mass

abnormal cerebral cortex morphology ( J:183998 )

• increase in cell density in cortical layers II/III, IV and V/VI at P7

• cell densities are also increased in adults

thickened cerebral cortex ( J:183998 )

• at P7 throughout the medial region

cardiovascular system

increased heart weight ( J:183998 )

cellular

abnormal mitosis ( J:183998 )

• significantly shorter S phase in neuronal progenitors at E15.5

abnormal neuron differentiation ( J:183998 )

• enhanced self-renewal in neuronal precursors at E13.5

abnormal neuronal precursor proliferation ( J:183998 )

• increase in the proportion of mitotic cells in the ventricular zone at E15.5

• increase in the number of BrdU positive cells in the neocortex at E13.5 and E15.5

• increase in the number of proliferating apical and intermediate/basal progenitor cells and in intermediate/basal progenitor cells in the neocortex at E13.5 and E15.5, respectively

• significantly shorter S phase in neuronal progenitors at E15.5

growth/size/body

increased heart weight ( J:183998 )

Allelic Composition	Smarca1^tm1.1Pick/Y Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Smarca1^tm1.1Pick mutation (0 available); any Smarca1 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:183998 )

N	• no increase in the proportion of mitotic cells or fraction of intermediate/basal progenitor cells is detected at E15.5 unlike in mutant mice wild-type for Foxg1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:183998 )

• enhanced self-renewal in neuronal precursors at E13.5

abnormal neuronal precursor proliferation ( J:183998 )

• increase in the proportion of mitotic cells in the ventricular zone at E15.5

• increase in the number of BrdU positive cells in the neocortex at E13.5 and E15.5

• increase in the number of proliferating apical and intermediate/basal progenitor cells and in intermediate/basal progenitor cells in the neocortex at E13.5 and E15.5, respectively

• significantly shorter S phase in neuronal progenitors at E15.5

abnormal telencephalon development ( J:183998 )

• expression analysis indicates potential changes to cell fate within layers V/VI at E15.5 and layer V at E17.5

increased cortical ventricular zone cell density ( J:183998 )

• increased cell density at E15.5

increased brain weight ( J:183998 )

• a 1.4 fold increase in brain:body mass ratio resulting from an increase in brain mass

abnormal cerebral cortex morphology ( J:183998 )

• increase in cell density in cortical layers II/III, IV and V/VI at P7

• cell densities are also increased in adults

thickened cerebral cortex ( J:183998 )

• at P7 throughout the medial region

cardiovascular system

increased heart weight ( J:183998 )

behavior/neurological

behavior/neurological phenotype ( J:183998 )

N	• perform as well as controls in several behavioral tests

cellular

abnormal mitosis ( J:183998 )

• significantly shorter S phase in neuronal progenitors at E15.5

abnormal neuron differentiation ( J:183998 )

• enhanced self-renewal in neuronal precursors at E13.5

abnormal neuronal precursor proliferation ( J:183998 )

• increase in the proportion of mitotic cells in the ventricular zone at E15.5

• increase in the number of BrdU positive cells in the neocortex at E13.5 and E15.5

• increase in the number of proliferating apical and intermediate/basal progenitor cells and in intermediate/basal progenitor cells in the neocortex at E13.5 and E15.5, respectively

• significantly shorter S phase in neuronal progenitors at E15.5

growth/size/body

increased heart weight ( J:183998 )

megacephaly ( J:183998 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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