nervous system
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• enhanced self-renewal in neuronal precursors at E13.5
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• increase in the proportion of mitotic cells in the ventricular zone at E15.5
• increase in the number of BrdU positive cells in the neocortex at E13.5 and E15.5
• increase in the number of proliferating apical and intermediate/basal progenitor cells and in intermediate/basal progenitor cells in the neocortex at E13.5 and E15.5, respectively
• significantly shorter S phase in neuronal progenitors at E15.5
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• expression analysis indicates potential changes to cell fate within layers V/VI at E15.5 and layer V at E17.5
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• increased cell density at E15.5
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• increase in brain:body mass ratio resulting from an increase in brain mass
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• increase in cell density in cortical layers II/III, IV and V/VI at P7
• cell densities are also increased in adults
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• at P7 throughout the medial region
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cardiovascular system
cellular
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• significantly shorter S phase in neuronal progenitors at E15.5
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• enhanced self-renewal in neuronal precursors at E13.5
|
|
• increase in the proportion of mitotic cells in the ventricular zone at E15.5
• increase in the number of BrdU positive cells in the neocortex at E13.5 and E15.5
• increase in the number of proliferating apical and intermediate/basal progenitor cells and in intermediate/basal progenitor cells in the neocortex at E13.5 and E15.5, respectively
• significantly shorter S phase in neuronal progenitors at E15.5
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growth/size/body