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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Smarca1tm1.1Pick
targeted mutation 1.1, David J Picketts
MGI:5427348
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Smarca1tm1.1Pick/Smarca1tm1.1Pick involves: 129S4/SvJae * CD-1 MGI:5427350
cx2
Smarca1tm1.1Pick/Y
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * 129S4/SvJae * CD-1 MGI:5427352
ot3
Smarca1tm1.1Pick/Y involves: 129S4/SvJae * CD-1 MGI:5427351


Genotype
MGI:5427350
hm1
Allelic
Composition
Smarca1tm1.1Pick/Smarca1tm1.1Pick
Genetic
Background
involves: 129S4/SvJae * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca1tm1.1Pick mutation (0 available); any Smarca1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• enhanced self-renewal in neuronal precursors at E13.5
• increase in the proportion of mitotic cells in the ventricular zone at E15.5
• increase in the number of BrdU positive cells in the neocortex at E13.5 and E15.5
• increase in the number of proliferating apical and intermediate/basal progenitor cells and in intermediate/basal progenitor cells in the neocortex at E13.5 and E15.5, respectively
• significantly shorter S phase in neuronal progenitors at E15.5
• expression analysis indicates potential changes to cell fate within layers V/VI at E15.5 and layer V at E17.5
• increased cell density at E15.5
• increase in brain:body mass ratio resulting from an increase in brain mass
• increase in cell density in cortical layers II/III, IV and V/VI at P7
• cell densities are also increased in adults
• at P7 throughout the medial region

cardiovascular system

cellular
• significantly shorter S phase in neuronal progenitors at E15.5
• enhanced self-renewal in neuronal precursors at E13.5
• increase in the proportion of mitotic cells in the ventricular zone at E15.5
• increase in the number of BrdU positive cells in the neocortex at E13.5 and E15.5
• increase in the number of proliferating apical and intermediate/basal progenitor cells and in intermediate/basal progenitor cells in the neocortex at E13.5 and E15.5, respectively
• significantly shorter S phase in neuronal progenitors at E15.5

growth/size/body




Genotype
MGI:5427352
cx2
Allelic
Composition
Smarca1tm1.1Pick/Y
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Smarca1tm1.1Pick mutation (0 available); any Smarca1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no increase in the proportion of mitotic cells or fraction of intermediate/basal progenitor cells is detected at E15.5 unlike in mutant mice wild-type for Foxg1




Genotype
MGI:5427351
ot3
Allelic
Composition
Smarca1tm1.1Pick/Y
Genetic
Background
involves: 129S4/SvJae * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca1tm1.1Pick mutation (0 available); any Smarca1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• enhanced self-renewal in neuronal precursors at E13.5
• increase in the proportion of mitotic cells in the ventricular zone at E15.5
• increase in the number of BrdU positive cells in the neocortex at E13.5 and E15.5
• increase in the number of proliferating apical and intermediate/basal progenitor cells and in intermediate/basal progenitor cells in the neocortex at E13.5 and E15.5, respectively
• significantly shorter S phase in neuronal progenitors at E15.5
• expression analysis indicates potential changes to cell fate within layers V/VI at E15.5 and layer V at E17.5
• increased cell density at E15.5
• a 1.4 fold increase in brain:body mass ratio resulting from an increase in brain mass
• increase in cell density in cortical layers II/III, IV and V/VI at P7
• cell densities are also increased in adults
• at P7 throughout the medial region

cardiovascular system

behavior/neurological
N
• perform as well as controls in several behavioral tests

cellular
• significantly shorter S phase in neuronal progenitors at E15.5
• enhanced self-renewal in neuronal precursors at E13.5
• increase in the proportion of mitotic cells in the ventricular zone at E15.5
• increase in the number of BrdU positive cells in the neocortex at E13.5 and E15.5
• increase in the number of proliferating apical and intermediate/basal progenitor cells and in intermediate/basal progenitor cells in the neocortex at E13.5 and E15.5, respectively
• significantly shorter S phase in neuronal progenitors at E15.5

growth/size/body





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory