Analysis Tools
nervous system
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• in treated mice, radial glial cells in the dentate gyrus displayed dislocated cell bodies into the granule layer and do not form a normal subgranular zone
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• decreased proliferation of neural stem cells and intermediate progenitor cells is observed in the dentate gyrus at P7 following tamoxifen treatment on P5
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• when tamoxifen is administered at P5, a significant increase in dentate gyrus size is observed
• volume of the suprapyramidal blade is decreased and only a fraction of the infrapyramidal blade develops
• when tamoxifen is administered at P5 and brains isolated at P7 following a 4 hr BrdU pulse, proliferating cells are reduced and scattered and migrating cells are absent; proliferating cells are reduced resulting in absence of the subgranular zone at P10 following tamoxifen administration at P5 and BrdU injection at P6
• when tamoxifen is administered at P5 and brains isolated at P14, a compact subgranular zone is not observed and radial glial (GFAP-positive) cells are disarrayed; migration defects in granule cells are observed, with calretinin positive immature neurons ectopically located inside and outside the granule layer in contrast to control brains
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cellular
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• in treated mice, radial glial cells in the dentate gyrus displayed dislocated cell bodies into the granule layer and do not form a normal subgranular zone
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• decreased proliferation of neural stem cells and intermediate progenitor cells is observed in the dentate gyrus at P7 following tamoxifen treatment on P5
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