Phenotypes associated with this allele

• Allele Symbol: Cacfd1^tm1.1Geno
• Allele Name: targeted mutation 1.1, Genoway
• Allele ID: MGI:5427429
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacfd1^tm1.1Geno/Cacfd1^tm1.1Geno	involves: 129S2/SvPas * C57BL/6J	MGI:5427432

Genotype
MGI:5427432

hm1

• Allelic Composition: Cacfd1^tm1.1Geno/Cacfd1^tm1.1Geno
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:184968 )

• mice exposed to DMBA/TPA exhibit reduced number of papillomas compared with wild-type mice

• 3 of 14 DMBA/TPA-treated mice do not develop tumors

increased tumor latency ( J:184968 )

• slightly delayed papilloma formation in DMBA/TPA-treated mice

cellular

increased apoptosis ( J:184968 )

• in papilloma and surrounding cells of DMBA/TPA-treated mice

decreased cell proliferation ( J:184968 )

• in papilloma cells of DMBA/TPA-treated mice

• however, cell proliferation of epidermis cells from untreated mice is normal

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:184968 )

• mice exposed to DMBA/TPA exhibit reduced number of papillomas compared with wild-type mice

• 3 of 14 DMBA/TPA-treated mice do not develop tumors