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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Apoetm3(APOE_i4)Yhg
targeted mutation 3, Yadong Huang
MGI:5427463
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Apoetm1Unc/Apoetm3(APOE_i4)Yhg
Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 MGI:5427502


Genotype
MGI:5427502
cx1
Allelic
Composition		 Apoetm1Unc/Apoetm3(APOE_i4)Yhg
Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Apoetm3(APOE_i4)Yhg mutation (0 available); any Apoe mutation (158 available)
Zbtb20Tg(PDGFB-APPSwInd)20Lms mutation (1 available); any Zbtb20 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:184138 )
• aged mice exhibit reduced amyloid plaques compared to Apoetm3(APOE_i4)Yhg/Apoetm3(APOE_i4)Yhg Tg(PDGFB-APPSwInd)20Lms mice

homeostasis/metabolism
amyloid beta deposits ( J:184138 )
• aged mice exhibit reduced amyloid plaques compared to Apoetm3(APOE_i4)Yhg/Apoetm3(APOE_i4)Yhg Tg(PDGFB-APPSwInd)20Lms mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory