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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Psen1tm3.1Shn
targeted mutation 3.1, Jie Shen
MGI:5427478
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Psen1tm3.1Shn/Psen1tm3.1Shn involves: 129 * C57BL/6 * C57BL/6J * CBA MGI:5427483
cx2
 		Psen1tm3.1Shn/Psen1tm3.1Shn
Psen2tm1Haa/Psen2tm1Haa 		involves: 129 * C57BL/6 * C57BL/6J * CBA MGI:5427484


Genotype
MGI:5427483
hm1
Allelic
Composition		 Psen1tm3.1Shn/Psen1tm3.1Shn
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm3.1Shn mutation (1 available); any Psen1 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:184454 )
N
• mice do not develop age-dependent neurogeneration with no tau pathology




Genotype
MGI:5427484
cx2
Allelic
Composition		 Psen1tm3.1Shn/Psen1tm3.1Shn
Psen2tm1Haa/Psen2tm1Haa
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm3.1Shn mutation (1 available); any Psen1 mutation (48 available)
Psen2tm1Haa mutation (0 available); any Psen2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spatial working memory ( J:184454 )
• mild impairment of spatial memory in a Morris water maze




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory