All Phenotypes Nrbp1<tm1.2Dja> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nrbp1^tm1.2Dja/Nrbp1^tm1.2Dja	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	MGI:5427572
cn2	Nrbp1^tm1.1Dja/Nrbp1^tm1.2Dja Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J	MGI:5427573
cn3	Nrbp1^tm1.1Dja/Nrbp1^tm1.2Dja Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J	MGI:5427571

Allelic Composition	Nrbp1^tm1.2Dja/Nrbp1^tm1.2Dja
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrbp1^tm1.2Dja mutation (0 available); any Nrbp1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:184685 )

• at E7.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

increased lung carcinoma incidence ( J:184685 )

• in tamoxifen-treated mice

mortality/aging

decreased tumor-free survival time ( J:184685 )

• moribund as early as 3 days post tamoxifen treatment

• 75% of mice die 9 days after tamoxifen treatment

• mice treated with a low dose of tamoxifen exhibit increased death associated with tumorigenesis

digestive/alimentary system

abnormal enterocyte proliferation ( J:184685 )

• tamoxifen-treated mice exhibit increased cell proliferation in the intestinal epithelium compared with control mice

abnormal intestine morphology ( J:184685 )

• loss of architecture in tamoxifen-treated mice with reduction in numbers of differentiated cells, cells showing dysplastic nuclear atypia, widespread crypt elongation, increased crypt fission and reduction in villous length

abnormal intestinal mucosa morphology ( J:184685 )

• in tamoxifen-treated mice

abnormal intestinal goblet cell morphology ( J:184685 )

• tamoxifen-treated mice exhibit a decrease of Alcian Blue positive goblet cells compared with control mice

abnormal intestinal enteroendocrine cell morphology ( J:184685 )

• reduced numbers in tamoxifen-treated mice

abnormal crypts of Lieberkuhn morphology ( J:184685 )

• elongated in tamoxifen-treated mice

ectopic Paneth cells ( J:184685 )

• altered distribution in tamoxifen-treated mice

intestinal edema ( J:184685 )

• in tamoxifen-treated mice

distended stomach ( J:184685 )

• in tamoxifen-treated mice

increased gastrointestinal tumor incidence ( J:184685 )

• in 6 of 16 tamoxifen-treated mice, 2 of which are adenomas with high-grade dysplasia and 2 are invasive adenocarcinoma

• 5 of 6 tumors are located in the caecum

neoplasm

increased tumor incidence ( J:184685 )

• tamoxifen-treated mice exhibit increased incidence of tumorigenesis, including lymphomas/leukemias and solid tumors (angiosarcoma, gastrointestinal adenoma, gastrointestinal adenocarcinoma and lung carcinoma)

increased gastrointestinal tumor incidence ( J:184685 )

• in 6 of 16 tamoxifen-treated mice, 2 of which are adenomas with high-grade dysplasia and 2 are invasive adenocarcinoma

• 5 of 6 tumors are located in the caecum

increased leukemia incidence ( J:184685 )

• in tamoxifen-treated mice

increased lymphoma incidence ( J:184685 )

• in tamoxifen-treated mice

increased lung carcinoma incidence ( J:184685 )

• in tamoxifen-treated mice

liver/biliary system

abnormal liver morphology ( J:184685 )

• tamoxifen-treated mice exhibit zone 3 hydropic changes indicative of malnutrition unlike control mice

homeostasis/metabolism

intestinal edema ( J:184685 )

• in tamoxifen-treated mice

cellular

abnormal intestinal goblet cell morphology ( J:184685 )

• tamoxifen-treated mice exhibit a decrease of Alcian Blue positive goblet cells compared with control mice

abnormal enterocyte proliferation ( J:184685 )

• tamoxifen-treated mice exhibit increased cell proliferation in the intestinal epithelium compared with control mice

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:184685 )

• elongated in tamoxifen-treated mice

ectopic Paneth cells ( J:184685 )

• altered distribution in tamoxifen-treated mice

Allelic Composition	Nrbp1^tm1.1Dja/Nrbp1^tm1.2Dja Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5^{tm1(cre/ERT2)Cle} mutation (1 available); any Lgr5 mutation (58 available)
Nrbp1^tm1.1Dja mutation (0 available); any Nrbp1 mutation (52 available)
Nrbp1^tm1.2Dja mutation (0 available); any Nrbp1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal intestine morphology ( J:184685 )

• authors state that tamoxifen-treated mice exhibit similar phenotype as Nrbp1^tm1.1Dja/Nrbp1^tm1.1Dja Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/ Gt(ROSA)26Sor⁺ mice

abnormal intestinal goblet cell morphology ( J:184685 )

• abnormal goblet cell production in tamoxifen-treated mice

abnormal Paneth cell morphology ( J:184685 )

• abnormal granularization of Paneth cells in tamoxifen-treated mice

ectopic Paneth cells ( J:184685 )

• abnormal localization of Paneth cells in tamoxifen-treated mice

endocrine/exocrine glands

abnormal Paneth cell morphology ( J:184685 )

• abnormal granularization of Paneth cells in tamoxifen-treated mice

ectopic Paneth cells ( J:184685 )

• abnormal localization of Paneth cells in tamoxifen-treated mice

cellular

abnormal intestinal goblet cell morphology ( J:184685 )

• abnormal goblet cell production in tamoxifen-treated mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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