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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hormad2tm1Atot
targeted mutation 1, Attila Toth
MGI:5427603
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hormad2tm1Atot/Hormad2tm1Atot involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd MGI:5427611
cx2
 		Hormad2tm1Atot/Hormad2tm1Atot
Spo11tm1Mjn/Spo11tm1Mjn 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd MGI:5427614


Genotype
MGI:5427611
hm1
Allelic
Composition		 Hormad2tm1Atot/Hormad2tm1Atot
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hormad2tm1Atot mutation (0 available); any Hormad2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:183982 )
N
• female fertility is normal
abnormal male meiosis ( J:183982 )
• slightly lower median foci numbers of RAD51, DMC1, and RPA in spermatocytes indicating a potential role in double strand break formation or repair
• incomplete and spatially limited sex body formation and an increase in the frequency of sex chromosome pairing defects
• expression analysis indicates a failure of meiotic sex chromosome inactivation
abnormal male germ cell apoptosis ( J:183982 )
• spermatocytes undergo apoptosis at a stage equivalent to mid-pachytene by the end of the epithelial cycle stage IV of testis tubules
arrest of spermatogenesis ( J:183982 )
• stage IV arrest

cellular
abnormal male meiosis ( J:183982 )
• slightly lower median foci numbers of RAD51, DMC1, and RPA in spermatocytes indicating a potential role in double strand break formation or repair
• incomplete and spatially limited sex body formation and an increase in the frequency of sex chromosome pairing defects
• expression analysis indicates a failure of meiotic sex chromosome inactivation
abnormal male germ cell apoptosis ( J:183982 )
• spermatocytes undergo apoptosis at a stage equivalent to mid-pachytene by the end of the epithelial cycle stage IV of testis tubules




Genotype
MGI:5427614
cx2
Allelic
Composition		 Hormad2tm1Atot/Hormad2tm1Atot
Spo11tm1Mjn/Spo11tm1Mjn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hormad2tm1Atot mutation (0 available); any Hormad2 mutation (33 available)
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:183982 )
N
• oocyte numbers are similar to wild-type females
abnormal meiosis ( J:183982 )
• significant decrease in the frequency of pseudo-sex bodies compared to mutant mice wild-type for Hormad2

cellular
abnormal meiosis ( J:183982 )
• significant decrease in the frequency of pseudo-sex bodies compared to mutant mice wild-type for Hormad2




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory