All Phenotypes Hormad2<tm1.2Atot> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hormad2^tm1.2Atot/Hormad2^tm1.2Atot	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL	MGI:5427612
cx2	Dmc1^tm1Jcs/Dmc1^tm1Jcs Hormad2^tm1.2Atot/Hormad2^tm1.2Atot	involves: 129 * BALB/c * C57BL/6 * SJL	MGI:5427616
cx3	Hormad2^tm1.2Atot/Hormad2^tm1.2Atot Spo11^tm1Mjn/Spo11^tm1Mjn	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL	MGI:5427615

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:183982 )

N	• female fertility is normal

abnormal chiasmata formation ( J:183982 )

• small but significant increase in the frequency of univalent containing metaphase I oocytes

abnormal female meiosis ( J:183982 )

• small but significant increase in the frequency of univalent containing metaphase I oocytes

abnormal male meiosis ( J:183982 )

• slightly lower median foci numbers of RAD51, DMC1, and RPA in spermatocytes indicating a potential role in double strand break formation or repair

• incomplete and spatially limited sex body formation and an increase in the frequency of sex chromosome pairing defects

• expression analysis indicates a failure of meiotic sex chromosome inactivation

abnormal male germ cell apoptosis ( J:183982 )

• spermatocytes undergo apoptosis at a stage equivalent to mid-pachytene by the end of the epithelial cycle stage IV of testis tubules

arrest of spermatogenesis ( J:183982 )

• stage IV arrest

male infertility ( J:183982 )

cellular

abnormal chiasmata formation ( J:183982 )

• small but significant increase in the frequency of univalent containing metaphase I oocytes

abnormal female meiosis ( J:183982 )

• small but significant increase in the frequency of univalent containing metaphase I oocytes

abnormal male meiosis ( J:183982 )

• slightly lower median foci numbers of RAD51, DMC1, and RPA in spermatocytes indicating a potential role in double strand break formation or repair

• incomplete and spatially limited sex body formation and an increase in the frequency of sex chromosome pairing defects

• expression analysis indicates a failure of meiotic sex chromosome inactivation

abnormal male germ cell apoptosis ( J:183982 )

• spermatocytes undergo apoptosis at a stage equivalent to mid-pachytene by the end of the epithelial cycle stage IV of testis tubules

Allelic Composition	Dmc1^tm1Jcs/Dmc1^tm1Jcs Hormad2^tm1.2Atot/Hormad2^tm1.2Atot
Genetic Background	involves: 129 * BALB/c * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1^tm1Jcs mutation (1 available); any Dmc1 mutation (17 available)
Hormad2^tm1.2Atot mutation (0 available); any Hormad2 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

absent oocytes ( J:183982 )

cellular

absent oocytes ( J:183982 )

Allelic Composition	Hormad2^tm1.2Atot/Hormad2^tm1.2Atot Spo11^tm1Mjn/Spo11^tm1Mjn
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hormad2^tm1.2Atot mutation (0 available); any Hormad2 mutation (33 available)
Spo11^tm1Mjn mutation (2 available); any Spo11 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:183982 )

N	• oocyte numbers are similar to wild-type females

abnormal meiosis ( J:183982 )

• significant decrease in the frequency of pseudo-sex bodies compared to mutant mice wild-type for Hormad2

cellular

abnormal meiosis ( J:183982 )

• significant decrease in the frequency of pseudo-sex bodies compared to mutant mice wild-type for Hormad2

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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