All Phenotypes Fuom<tm1Ckp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fuom^tm1Ckp
targeted mutation 1, Chankyu Park
MGI:5427618

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fuom^tm1Ckp/Fuom^tm1Ckp	involves: 129P2/OlaHsd * C57BL/6	MGI:5427619
ht2	Fuom^tm1Ckp/Fuom⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5427620

Allelic Composition	Fuom^tm1Ckp/Fuom^tm1Ckp
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fuom^tm1Ckp mutation (0 available); any Fuom mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:185112 )

• minor

abnormal sexual interaction ( J:185112 )

• ovariectomized mice exhibit masculinized coital behaviors compared with control mice

• intact and ovariectomized female mice prefer female urine unlike control mice

• however, masculinized coital behaviors are rescued by 17beta-estradiol treatment

abnormal mating receptivity ( J:185112 )

• female mice avoid normal male partners

• ovariectomized mice treated with 17beta-estradiol exhibit reduced sexual receptivity (noted by lordosis) with occasional mating by forced intromission compared with control mice

growth/size/body

decreased body weight ( J:185112 )

• slight

skeleton

abnormal spine curvature ( J:185112 )

• ovariectomized mice exhibit a suppression of lordosis induced by 17beta-estradiol treatment compared with control mice

Allelic Composition	Fuom^tm1Ckp/Fuom⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6