Phenotypes associated with this allele

• Allele Symbol: Kif17^tm1Noh
• Allele Name: targeted mutation 1, Nobutaka Hirokawa
• Allele ID: MGI:5427632
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kif17^tm1Noh/Kif17^tm1Noh	Not Specified	MGI:5427640

Genotype
MGI:5427640

hm1

• Allelic Composition: Kif17^tm1Noh/Kif17^tm1Noh
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axonal transport ( J:174822 )

• anterograde transport velocity is decreased compared to in wild-type neurons

impaired synaptic plasticity ( J:174822 )

reduced NMDA-mediated synaptic currents ( J:174822 )

• reduced NMDA receptor-mediated excitatory postsynaptic currents

reduced long-term potentiation ( J:174822 )

• mice exhibit a decrease in early long term potentiation and progressively decaying potentiation throughout the duration of recording compared with wild-type mice

reduced long-term depression ( J:174822 )

• a low frequency train of 1 Hz for 15 minutes failed to evoke long term depression unlike in wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:174822 )

N • mice exhibit normal olfactory learning

impaired contextual conditioning behavior ( J:174822 )

impaired long-term object recognition memory ( J:174822 )

• mice exhibit impaired preference for a novel object after 6 hr and 1 day retention sessions compared with wild-type mice

abnormal spatial learning ( J:174822 )

• in a Morris water maze test with hidden platform