Phenotypes associated with this allele

• Allele Symbol: Nek6^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:5427679
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nek6^tm1Dgen/Nek6^tm1Dgen	involves: 129S1/Sv * 129X1/SvJ	MGI:5606182
hm2	Nek6^tm1Dgen/Nek6^tm1Dgen	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5427837

Genotype
MGI:5606182

hm1

• Allelic Composition: Nek6^tm1Dgen/Nek6^tm1Dgen
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:215160 )

♂ • mice show a greater increase in cardiomyocyte cross-sectional area 4 weeks after TAC than wild-type mice

increased heart weight ( J:215160 )

♂ • 4 weeks after transthoracic aorta constriction (TAC), mutants show a more pronounced increase in heart weight than wild-type mice

cardiac hypertrophy ( J:215160 )

♂ • mice show aggravated cardiac hypertrophy 4 weeks after TAC

cardiac interstitial fibrosis ( J:215160 )

♂ • 4 weeks after TAC, cardiac fibrosis is much more prominent in mutants than in wild-type mice

decreased heart left ventricle muscle contractility ( J:215160 )

♂ • left ventricle ejection fraction and fractional shortening are decreased in mice 4 weeks after TAC

increased response of heart to induced stress ( J:215160 )

♂ • 4 weeks after transthoracic aorta constriction (TAC), mutants show a more pronounced increase in heart weight, a higher increase in lung weight/body weight, aggravated cardiac hypertrophy, a greater increase in cardiomyocyte cross-sectional area, in both both left ventricle end-systolic and end-diastolic diameters (LVESD and LVEDD), and cardiac fibrosis, and decreased LV ejection fraction and fractional shortening than wild-type mice

homeostasis/metabolism

increased response of heart to induced stress ( J:215160 )

♂ • 4 weeks after transthoracic aorta constriction (TAC), mutants show a more pronounced increase in heart weight, a higher increase in lung weight/body weight, aggravated cardiac hypertrophy, a greater increase in cardiomyocyte cross-sectional area, in both both left ventricle end-systolic and end-diastolic diameters (LVESD and LVEDD), and cardiac fibrosis, and decreased LV ejection fraction and fractional shortening than wild-type mice

muscle

increased myocardial fiber size ( J:215160 )

♂ • mice show a greater increase in cardiomyocyte cross-sectional area 4 weeks after TAC than wild-type mice

decreased heart left ventricle muscle contractility ( J:215160 )

♂ • left ventricle ejection fraction and fractional shortening are decreased in mice 4 weeks after TAC

respiratory system

increased lung weight ( J:215160 )

♂ • 4 weeks after TAC, mutants show a higher increase in lung weight/body weight compared to wild-type mice

growth/size/body

increased heart weight ( J:215160 )

♂ • 4 weeks after transthoracic aorta constriction (TAC), mutants show a more pronounced increase in heart weight than wild-type mice

cardiac hypertrophy ( J:215160 )

♂ • mice show aggravated cardiac hypertrophy 4 weeks after TAC

increased lung weight ( J:215160 )

♂ • 4 weeks after TAC, mutants show a higher increase in lung weight/body weight compared to wild-type mice

cellular

cardiac interstitial fibrosis ( J:215160 )

♂ • 4 weeks after TAC, cardiac fibrosis is much more prominent in mutants than in wild-type mice

Genotype
MGI:5427837

hm2

• Allelic Composition: Nek6^tm1Dgen/Nek6^tm1Dgen
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

normal phenotype

no abnormal phenotype detected ( J:82809 )

• no significant differences detected in the homozygous mutant and heterozygous mutant animals when compared with age- and gender-matched wild-type control mice