renal/urinary system
• natriuretic effect of hydrochlorothiazide is almost abolished
|
• when on a normal or low salt diet
• infusion of AngII fails to reduce Na+ secretion at day 1 unlike in wild-type controls
|
• when on a normal or low salt diet
|
• when on a normal diet
• infusion of AngII fails to reduce Na+ secretion at day 1 unlike in wild-type controls
• however, on a low salt diet mice are able to reduce Na+ excretion similarly to wild-type controls
|
• increase in urinary volume but, no difference in body weight, mice do not appear dehydrated and the ability to concentrate urine is similar to controls
|
homeostasis/metabolism
N |
• circulating calcium levels are normal
|
• infusion of AngII fails to increase plasma aldosterone concentration unlike in wild-type controls
|
• when on a normal diet
|
hypokalemia
(
J:184790
)
• mild when on a normal diet
• hypokalemia is aggravated when on a low K+ diet
• on a high K+ diet no difference in K+ levels are seen compared to controls
|
• increase in plasm renin activity
|
• mild hypochloremia when on a normal diet
|
• when on a normal or low salt diet
• infusion of AngII fails to reduce Na+ secretion at day 1 unlike in wild-type controls
|
• when on a normal or low salt diet
|
• when on a normal diet
• infusion of AngII fails to reduce Na+ secretion at day 1 unlike in wild-type controls
• however, on a low salt diet mice are able to reduce Na+ excretion similarly to wild-type controls
|
• natriuretic effect of hydrochlorothiazide is almost abolished
|
cardiovascular system
N |
• systolic blood pressure is similar to wild-type controls
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Gitelman syndrome | DOID:0050450 |
OMIM:263800 |
J:184790 |