Phenotypes associated with this allele

• Allele Symbol: Rgs7^tm1.1Kama
• Allele Name: targeted mutation 1.1, Kirill Martemyanov
• Allele ID: MGI:5427707
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rgs7^tm1.1Kama/Rgs7^tm1.1Kama	involves: 129 * C57BL/6 * FVB/N * SJL	MGI:5427734
cx2	Rgs11^tm1Lex/Rgs11^tm1Lex Rgs7^tm1.1Kama/Rgs7^tm1.1Kama	involves: 129S5/SvEvBrd * C57BL/6 * FVB/N * SJL	MGI:5427735

Genotype
MGI:5427734

hm1

• Allelic Composition: Rgs7^tm1.1Kama/Rgs7^tm1.1Kama
• Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:184794 )

N • mice exhibit normal retinal light response of rod ON bipolar cells

Genotype
MGI:5427735

cx2

• Allelic Composition: Rgs11^tm1Lex/Rgs11^tm1Lex; Rgs7^tm1.1Kama/Rgs7^tm1.1Kama
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * FVB/N * SJL

vision/eye

abnormal rod electrophysiology ( J:184794 )

• mice lack dark-adapted electroretinogram b-wave

nervous system

abnormal single cell response ( J:184794 )

• rod ON bipolar cells lack a flash response and exhibit a 40-folder shorter light-evoked response compared with wild-type cells