behavior/neurological
N |
• immunotoxin-injected mice exhibit normal spontaneous locomotion, motor learning and motivational behavior
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• in a two-choice reaction time task dependent on light stimulus, immunotoxin-injected mice exhibit lengthened motor response compared with wild-type mice
• however, accuracy is normal
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nervous system
• following unilateral injection of immunotoxin, mice exhibit a loss DRD1A- and preprotachykinin-A (PPTA/TAC1)-containing neurons restricted to the dorsal region of the striatum
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