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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc21tm1.1Kry
targeted mutation 1.1, Gerard Karsentry
MGI:5427919
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mirc21tm1.1Kry/Mirc21tm1.1Kry
Satb2tm1Rug/Satb2+
Tg(Col1a1-cre)1Kry/0 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N MGI:5427924
cn2
 		Mirc21tm1.1Kry/Mirc21tm1.1Kry
Tg(Col1a1-cre)1Kry/0 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N MGI:5427925
cn3
 		Mir34atm1.1Kry/Mir34atm1.1Kry
Mirc21tm1.1Kry/Mirc21tm1.1Kry
Tg(Col1a1-cre)1Kry/0 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N MGI:5427926


Genotype
MGI:5427924
cn1
Allelic
Composition		 Mirc21tm1.1Kry/Mirc21tm1.1Kry
Satb2tm1Rug/Satb2+
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc21tm1.1Kry mutation (0 available); any Mirc21 mutation (5 available)
Satb2tm1Rug mutation (0 available); any Satb2 mutation (43 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:185130 )
N
• mice exhibit normal bone mass, bone formation rate and osteoblast numbers




Genotype
MGI:5427925
cn2
Allelic
Composition		 Mirc21tm1.1Kry/Mirc21tm1.1Kry
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc21tm1.1Kry mutation (0 available); any Mirc21 mutation (5 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Increased bone mass in Mirc21tm1.1Kry/Mirc21tm1.1Kry Tg(Col1a1-cre)1Kry/0 mice

skeleton
skeleton phenotype ( J:185130 )
N
• osteoclast surface is normal
• mice exhibit normal growth plate development
increased osteoblast proliferation ( J:185130 )
• increased osteoblast proliferation compared with controls
• however, osteoblast apoptosis is normal
increased bone mass ( J:185130 )
• at 3 months
abnormal skeleton development ( J:185130 )
• increased bone formation rate compared with controls
enhanced osteoblast differentiation ( J:185130 )
• during embryonic development

cellular
enhanced osteoblast differentiation ( J:185130 )
• during embryonic development
increased osteoblast proliferation ( J:185130 )
• increased osteoblast proliferation compared with controls
• however, osteoblast apoptosis is normal




Genotype
MGI:5427926
cn3
Allelic
Composition		 Mir34atm1.1Kry/Mir34atm1.1Kry
Mirc21tm1.1Kry/Mirc21tm1.1Kry
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir34atm1.1Kry mutation (0 available); any Mir34a mutation (9 available)
Mirc21tm1.1Kry mutation (0 available); any Mirc21 mutation (5 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Increased bone mass in Mir34atm1.1Kry/Mir34atm1.1Kry Mirc21tm1.1Kry/Mirc21tm1.1Kry Tg(Col1a1-cre)1Kry/0 mice

skeleton
skeleton phenotype ( J:185130 )
N
• osteoclast surface is normal
increased bone mass ( J:185130 )
• at 3 months
abnormal skeleton development ( J:185130 )
• increased bone formation rate




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory