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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fcgr2btm1.2Jsv
targeted mutation 1.2, J Sjef Verbeek
MGI:5427927
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Fcgr2btm1Ttk/Fcgr2btm1.2Jsv
Sle21129P2/Ola/Sle21C57BL/6 		involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N MGI:5427953
cx2
 		Fcgr2btm1.2Jsv/Fcgr2btm1.2Jsv
Sle16C57BL/6/Sle16C57BL/6 		involves: C57BL/6 * FVB/N MGI:5427949
cx3
 		Fcgr2btm1.2Jsv/Fcgr2b+
X/Yaa 		involves: C57BL/6 * FVB/N * SB/Le MGI:5427950


Genotype
MGI:5427953
cx1
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1.2Jsv
Sle21129P2/Ola/Sle21C57BL/6
Genetic
Background		 involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1.2Jsv mutation (1 available); any Fcgr2b mutation (49 available)
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Sle21129P2/Ola mutation (0 available); any Sle21 mutation (0 available)
Sle21C57BL/6 mutation (0 available); any Sle21 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:179175 )
• mice exhibit greater cumulative death compared with wild-type C57BL/6 mice

immune system
enlarged spleen ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
increased spleen weight ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
increased anti-chromatin antibody level ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
increased anti-histone antibody level ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes

renal/urinary system
albuminuria ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
abnormal kidney morphology ( J:179175 )
• kidney pathology is increased compared to in wild-type C57BL/6 mice

homeostasis/metabolism
albuminuria ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes

hematopoietic system
enlarged spleen ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
increased spleen weight ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes

growth/size/body
enlarged spleen ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes
increased spleen weight ( J:179175 )
• not as severe as in Fcgr2btm1Ttk homozygotes




Genotype
MGI:5427949
cx2
Allelic
Composition		 Fcgr2btm1.2Jsv/Fcgr2btm1.2Jsv
Sle16C57BL/6/Sle16C57BL/6
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1.2Jsv mutation (1 available); any Fcgr2b mutation (49 available)
Sle16C57BL/6 mutation (0 available); any Sle16 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
albuminuria ( J:179175 )
• mild
kidney inflammation ( J:179175 )
• in a nephrotoxic nephritis model
• however, lower incidence and delayed onset compared to in Fcgr2btm1Ttk homozygotes
abnormal renal glomerulus morphology ( J:179175 )
• at 8 months, mice develop mild nonlethal glomerular damage compared with wild-type mice

immune system
immune system phenotype ( J:179175 )
N
• unlike Fcgr2btm1Ttk homozygotes, mice do not develop high anti-nuclear antibodies titers spontaneously or increased spleen weight
abnormal adaptive immunity ( J:179175 )
• mice exhibit increased antibody response after immunization, in mast cell-mediated cutaneous anaphylaxis, and in phagocytosis of immune complex (IC) by macrophages compared with control mice
increased immunoglobulin level ( J:179175 )
• kidney IgG and C3 depositions in a nephrotoxic nephritis model
increased susceptibility to induced arthritis ( J:179175 )
• collagen or K/BXN serum-induced
• however, lower incidence and delayed onset compared to in Fcgr2btm1Ttk homozygotes
kidney inflammation ( J:179175 )
• in a nephrotoxic nephritis model
• however, lower incidence and delayed onset compared to in Fcgr2btm1Ttk homozygotes

skeleton
increased susceptibility to induced arthritis ( J:179175 )
• collagen or K/BXN serum-induced
• however, lower incidence and delayed onset compared to in Fcgr2btm1Ttk homozygotes

homeostasis/metabolism
abnormal glomerular capillary thrombosis ( J:179175 )
• in a nephrotoxic nephritis model
albuminuria ( J:179175 )
• mild

hematopoietic system
increased immunoglobulin level ( J:179175 )
• kidney IgG and C3 depositions in a nephrotoxic nephritis model




Genotype
MGI:5427950
cx3
Allelic
Composition		 Fcgr2btm1.2Jsv/Fcgr2b+
X/Yaa
Genetic
Background		 involves: C57BL/6 * FVB/N * SB/Le
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1.2Jsv mutation (1 available); any Fcgr2b mutation (49 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:179175 )
• mice exhibit greater cumulative death compared with Fcgr2btm1.2Sjv homozygotes

immune system
enlarged spleen ( J:179175 )
• compared with Fcgr2btm1.2Sjv homozygotes
increased monocyte cell number ( J:179175 )
• compared with single homozygotes
increased susceptibility to systemic lupus erythematosus ( J:179175 )
• mice develop moderate lupus unlike Fcgr2btm1.2Sjv homozygotes
• however, mice do not develop fatal lupus
increased anti-chromatin antibody level ( J:179175 )
• compared with single homozygotes
increased anti-double stranded DNA antibody level ( J:179175 )
• compared with single homozygotes

renal/urinary system
abnormal kidney morphology ( J:179175 )
• kidney pathology is increased compared to in Fcgr2btm1.2Sjv homozygotes

hematopoietic system
enlarged spleen ( J:179175 )
• compared with Fcgr2btm1.2Sjv homozygotes
increased monocyte cell number ( J:179175 )
• compared with single homozygotes

growth/size/body
enlarged spleen ( J:179175 )
• compared with Fcgr2btm1.2Sjv homozygotes




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory