All Phenotypes Gata4<tm1Grg> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gata4^tm1Grg
targeted mutation 1, Vidu Garg
MGI:5427934

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata4^tm1Grg/Gata4^tm1Grg	involves: 129 * C57BL/6	MGI:5427935
ht2	Gata4^tm1Grg/Gata4⁺	involves: 129 * C57BL/6	MGI:5427936
cn3	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Nkx2-5-cre)9Eno/0	involves: 129 * C57BL/6	MGI:5427940
cn4	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Myh6-cre)2182Mds/0	involves: 129 * C57BL/6 * FVB/N	MGI:5427939
cn5	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Tek-cre)1Ywa/0	involves: 129 * C57BL/6 * SJL	MGI:5427937

Allelic Composition	Gata4^tm1Grg/Gata4^tm1Grg
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1Grg mutation (1 available); any Gata4 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Growth retardation and a thin myocardium in Gata4^tm1Grg/Gata4^tm1Grg mice

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:185124 )

• die between E10.5 and E11.5

growth/size/body

embryonic growth retardation ( J:185124 )

• severe growth retardation at E9.5 and E10.5

cardiovascular system

thin myocardium ( J:185124 )

• severe thinning at E10.5

delayed heart looping ( J:185124 )

• some embryos show delayed or incomplete looping at E9.5 and E10.5

thin ventricular wall ( J:185124 )

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E9.5

cellular

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E9.5

embryo

embryonic growth retardation ( J:185124 )

• severe growth retardation at E9.5 and E10.5

muscle

thin myocardium ( J:185124 )

• severe thinning at E10.5

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E9.5

Allelic Composition	Gata4^tm1Grg/Gata4⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1Grg mutation (1 available); any Gata4 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Atrial septal defects and semilunar valve stenosis in Gata4^tm1Grg/Gata4⁺ mice

cardiovascular system

aorta stenosis ( J:185124 )

• in 4 of 12 mutants

thin ventricle myocardium compact layer ( J:185124 )

abnormal heart atrium morphology ( J:185124 )

• thin

atrial septal defect ( J:185124 )

patent cardiac foramen ovale ( J:185124 )

• increase in the frequency of mice with intermittent shunting of blood between the atria

thick aortic valve cusps ( J:185124 )

• thickened aortic valve leaflets

thick pulmonary valve cusps ( J:185124 )

• thickened pulmonary valve leaflets

pulmonary valve stenosis ( J:185124 )

• in 2 of 12 mutants

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E11.5 and E13.5

cellular

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E11.5 and E13.5

muscle

thin ventricle myocardium compact layer ( J:185124 )

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E11.5 and E13.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atrial heart septal defect 2		DOID:0110107	OMIM:607941	J:185124

Allelic Composition	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Nkx2-5-cre)9Eno/0
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1.1Wtp mutation (0 available); any Gata4 mutation (36 available)
Gata4^tm1Grg mutation (1 available); any Gata4 mutation (36 available)
Tg(Nkx2-5-cre)9Eno mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Growth retardation and myocardial thinning in Gata4^tm1.1Wtp/Gata4^tm1Grg Tg(Nkx2-5-cre)9Eno/0 mice

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:185124 )

• at E10.5

growth/size/body

embryonic growth retardation ( J:185124 )

• severe

cardiovascular system

thin myocardium ( J:185124 )

embryo

embryonic growth retardation ( J:185124 )

• severe

muscle

thin myocardium ( J:185124 )

Allelic Composition	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Hearts of Gata4^tm1.1Wtp/Gata4^tm1Grg Tg(Myh6-cre)2182Mds/0 mice appear normal

normal phenotype

no abnormal phenotype detected ( J:185124 )

• viable with no signs of embryonic growth retardation or myocardial thinning

Allelic Composition	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Hypocellular endocardial cushions in Gata4^tm1.1Wtp/Gata4^tm1Grg Tg(Tek-cre)1Ywa/0 mice

cardiovascular system

abnormal atrioventricular cushion morphology ( J:185124 )

• hypocellular endocardial cushions are noted at E10.5

• however, no myocardial thinning is seen

growth/size/body

growth/size/body region phenotype ( J:185124 )

N	• viable with no signs of embryonic growth retardation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24