Analysis Tools
hematopoietic system
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• without affecting architecture
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• in adult mice
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• mice exhibit an increase in ProE and Ery.A fractions but a decrease in Ery.B and Ery.C in the bone marrow compared with control mice
• mice exhibit an increase in ProE and Ery.A fractions but a decrease in Ery.C in the spleen compared with control mice
• early erythropoiesis is partially blocked in association with a cell cycle defect
• proerythroblast exhibit reduced proliferation compared with control cells
• however, proerythroblast apoptosis rates are normal
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• decrease in the granulocyte macrophage progenitor (GMP) cells in the bone marrow
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• ProE cells are increased 3.6- and 74-fold in the bone marrow and spleen compared with control mice
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• in the bone marrow
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• 4.7-fold in the spleen
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• secondary
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• early long and short term hematopoietic stem cells are increased compared to in control mice
• however, the number of lymphoid-primed multipotent progenitors is normal and the increased in hematopoietic stem cells disappears in the alter stages of differentiation
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• increase in the megakaryocyte-erythroid progenitor (MEP) cells in the spleen
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• reduced half-life
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liver/biliary system
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• in adult mice
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pale liver
(
J:185179
)
renal/urinary system
pale kidney
(
J:185179
)
cellular
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• proerythroblast exhibit reduced proliferation compared with control cells
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integument
immune system
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• without affecting architecture
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• in adult mice
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endocrine/exocrine glands
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• without affecting architecture
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growth/size/body
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• in adult mice
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• in adult mice
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