Phenotypes associated with this allele

• Allele Symbol: Nefm^tm1Milg
• Allele Name: targeted mutation 1, Michael L Garcia
• Allele ID: MGI:5428135
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nefm^tm1Milg/Nefm^tm1Milg	involves: 129S/SvEv * C57BL/6	MGI:5428138

Genotype
MGI:5428138

hm1

• Allelic Composition: Nefm^tm1Milg/Nefm^tm1Milg
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:184861 )

N • motor nerve conduction velocity is normal

abnormal neuron differentiation ( J:184861 )

• large motor axons exhibit increased radial growth compared to in wild-type mice

• however, neurofilament spacing or clustering in small and large motor axons is normal

abnormal myelin sheath morphology ( J:184861 )

• at 6 months, small and large motor axons exhibit reduced myelin thickness compared to in wild-type mice

• however, myelin structure is normal

abnormal myelination ( J:184861 )

• motor neurons exhibit attenuated myelin expansion compared to in wild-type mice

cellular

abnormal neuron differentiation ( J:184861 )

• large motor axons exhibit increased radial growth compared to in wild-type mice

• however, neurofilament spacing or clustering in small and large motor axons is normal