Phenotypes associated with this allele

• Allele Symbol: Hprt1^{tm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno}
• Allele Name: targeted mutation 1, Genoway
• Allele ID: MGI:5428335
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Hprt1^tm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt1^+ Tg(PSEN1)5Dbo/0	involves: 129P2/OlaHsd	MGI:5428425

Genotype
MGI:5428425

cx1

• Allelic Composition: Hprt1^{tm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno}/Hprt1⁺; Tg(PSEN1)5Dbo/0
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:180977 )

♀ • at 5 months, mice exhibit impaired social recognition memory compared with control mice

♀ • at 12 months, mice lack social recognition memory unlike control mice

impaired short-term object recognition memory ( J:180977 )

♀ • impaired at 8 months

♀ • amnesia at 12 months

abnormal spatial reference memory ( J:180977 )

♀ • at 12 months, mice exhibit impaired object recognition following spatial displacement compared with control mice

abnormal spatial working memory ( J:180977 )

♀ • impaired at 12 months

abnormal motor coordination/balance ( J:180977 )

♀ • mice exhibit higher swim speeds compared with control mice

hyperactivity ( J:180977 )

♀ • at 12 months, mice fail to exhibit a decline in activity during the day phase unlike control mice

fragmentation of sleep/wake states ( J:180977 )

♀ • at 5 months mice exhibit increased wake time compared with control mice

♀ • at 5 and 12 months, mice exhibit a decrease in rapid eye movement (REM) sleep compared with control mice

♀ • at 5 months, mice exhibit a reduction in nonREM sleep compared with control mice

♀ • at 12 months mice exhibit longer latency to sleep onset compared with control mice

nervous system

nervous system phenotype ( J:180977 )

♀N • mice do not develop fibrillary plaques or tangles

abnormal brain wave pattern ( J:180977 )

♀ • mice exhibit a slowing of electroencephalogram compared with control mice

abnormal long-term potentiation ( J:180977 )

♀ • mice exhibit faster decay of long term potentiation compared with control mice

♀ • however, post-tetanic potentiation is normal

decreased paired-pulse facilitation ( J:180977 )

♀

homeostasis/metabolism

abnormal glucose homeostasis ( J:180977 )

♀ • mice exhibit early and progressive brain glucose metabolism compared with control mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:180977