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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Atoh7-cre)360Gla
transgene insertion 360, Tom Glaser
MGI:5428439
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Atoh7tm1.1(Ascl1)Nlbr/Atoh7tm1.1(Ascl1)Nlbr
Tg(Atoh7-cre)360Gla/0
Tg(CAG-Bgeo/GFP)21Lbe/0 		either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL) MGI:5529143
cn2
 		Atoh7tm1.1(Ascl1)Nlbr/Atoh7+
Tg(Atoh7-cre)360Gla/0
Tg(CAG-Bgeo/GFP)21Lbe/0 		either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL) MGI:5529144


Genotype
MGI:5529143
cn1
Allelic
Composition		 Atoh7tm1.1(Ascl1)Nlbr/Atoh7tm1.1(Ascl1)Nlbr
Tg(Atoh7-cre)360Gla/0
Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic
Background		 either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7tm1.1(Ascl1)Nlbr mutation (0 available); any Atoh7 mutation (9 available)
Tg(Atoh7-cre)360Gla mutation (0 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
increased retina apoptosis ( J:203642 )
• increased retinal apoptosis at E12.5 to E16.5
decreased retina ganglion cell number ( J:203642 )
• cell autonomous phenotype
increased retina cone cell number ( J:203642 )
• cell nonautonomous phenotype
abnormal retina progenitor cell morphology ( J:203642 )
• at E12.5 and E13.5, retinal progenitor cells exhibit a block to cell cycle progression and retinal ganglion cell differentiation

nervous system
decreased retina ganglion cell number ( J:203642 )
• cell autonomous phenotype
increased retina cone cell number ( J:203642 )
• cell nonautonomous phenotype

cellular
abnormal cell cycle ( J:203642 )
• at E12.5 and E13.5, retinal progenitor cells exhibit a block to cell cycle progression
increased retina apoptosis ( J:203642 )
• increased retinal apoptosis at E12.5 to E16.5




Genotype
MGI:5529144
cn2
Allelic
Composition		 Atoh7tm1.1(Ascl1)Nlbr/Atoh7+
Tg(Atoh7-cre)360Gla/0
Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic
Background		 either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7tm1.1(Ascl1)Nlbr mutation (0 available); any Atoh7 mutation (9 available)
Tg(Atoh7-cre)360Gla mutation (0 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
decreased retina rod cell number ( J:203642 )
• small autonomous loss
abnormal retina development ( J:203642 )
• delayed retinal ganglion cell differentiation
• however, adult mice exhibit normal proportion of retinal ganglion cells

nervous system
decreased retina rod cell number ( J:203642 )
• small autonomous loss




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory