Phenotypes associated with this allele

• Allele Symbol: Reck^tm2.2Noda
• Allele Name: targeted mutation 2.2, Makoto Noda
• Allele ID: MGI:5428466
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Reck^tm1.1Noda/Reck^tm2.2Noda	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj	MGI:5428662
cn2	Reck^tm2.1Noda/Reck^tm2.2Noda Tg(Prrx1-cre)1Cjt/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N * SJL/J	MGI:5428660
cn3	Reck^tm2.1Noda/Reck^tm2.2Noda Tg(Col2a1-cre)1Bhr/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:5428659
cn4	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^+ Reck^tm2.2Noda/Reck^tm3.1(cre/ERT2)Noda	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:5428661

Genotype
MGI:5428662

ht1

• Allelic Composition: Reck^tm1.1Noda/Reck^tm2.2Noda
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal limb morphology ( J:184585 )

• with multiple cutaneous horns on the dorsal side of the extremities

abnormal limb bud morphology ( J:184585 )

• as early as E12.5 in the forelimb buds

• the posterior side is hypoplastic

• poor chondrocyte condensation

• increased cell density in the central area and uneven, spongy distribution of cells in the marginal areas

• hypoplastic without an increase in apoptosis

• the dorsal ectoderm cells exhibit altered appearance

abnormal apical ectodermal ridge morphology ( J:184585 )

• flattened

abnormal digit morphology ( J:184585 )

• fingertip bones are round and porous in all limbs

abnormal forelimb morphology ( J:184585 )

• in some mice one or both of the forelimbs are pointing backwards

• mice exhibit loss of postaxial forelimb structures with variable severity

• more severe in the right forelimb

absent ulna ( J:184585 )

• in some mice with forelimb pointing backward

embryo

abnormal limb bud morphology ( J:184585 )

• as early as E12.5 in the forelimb buds

• the posterior side is hypoplastic

• poor chondrocyte condensation

• increased cell density in the central area and uneven, spongy distribution of cells in the marginal areas

• hypoplastic without an increase in apoptosis

• the dorsal ectoderm cells exhibit altered appearance

abnormal apical ectodermal ridge morphology ( J:184585 )

• flattened

skeleton

absent ulna ( J:184585 )

• in some mice with forelimb pointing backward

Genotype
MGI:5428660

cn2

• Allelic Composition: Reck^tm2.1Noda/Reck^tm2.2Noda; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N * SJL/J

skeleton

skeleton phenotype ( J:184585 )

N • authors state that mice exhibit the same defects as in Reck^tm1.1Noda/Reck^tm2.1Noda mice

Genotype
MGI:5428659

cn3

• Allelic Composition: Reck^tm2.1Noda/Reck^tm2.2Noda; Tg(Col2a1-cre)1Bhr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

limbs/digits/tail

limbs/digits/tail phenotype ( J:184585 )

N • mice exhibit normal limb patterning

Genotype
MGI:5428661

cn4

• Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺; Reck^tm2.2Noda/Reck^{tm3.1(cre/ERT2)Noda}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

limbs/digits/tail

abnormal limb development ( J:184585 )

• mice exhibit abnormal distribution of Reck+ cells compared with control mice