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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sprntm1Geno
targeted mutation 1, Genoway
MGI:5428663
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sprntm1Geno/Sprntm1Geno involves: 129S2/SvPas * C57BL/6J MGI:5428670
hm2
Sprntm1Geno/Sprntm1Geno involves: 129S2/SvPas * C57BL/6J * FVB/NCr MGI:5428671
cx3
Prnptm1Cwe/Prnptm1Cwe
Sprntm1Geno/Sprntm1Geno
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N MGI:5428672


Genotype
MGI:5428670
hm1
Allelic
Composition
Sprntm1Geno/Sprntm1Geno
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sprntm1Geno mutation (0 available); any Sprn mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit normal survival following prion infection

growth/size/body
• in female mice between P8 and P16
• in male mice between P28 and P42




Genotype
MGI:5428671
hm2
Allelic
Composition
Sprntm1Geno/Sprntm1Geno
Genetic
Background
involves: 129S2/SvPas * C57BL/6J * FVB/NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sprntm1Geno mutation (0 available); any Sprn mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• in male mice at P22
• in male mice between P29 and P50




Genotype
MGI:5428672
cx3
Allelic
Composition
Prnptm1Cwe/Prnptm1Cwe
Sprntm1Geno/Sprntm1Geno
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Cwe mutation (37 available); any Prnp mutation (142 available)
Sprntm1Geno mutation (0 available); any Sprn mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit normal survival unlike Prnptm1Cwe homozygotes

behavior/neurological
• as in Prnptm1Cwe homozygotes
• as in Prnptm1Cwe homozygotes
• as in Prnptm1Cwe homozygotes
• as in Prnptm1Cwe homozygotes

nervous system
N
• unlike Prnptm1Cwe homozygotes, mice do not exhibit dysmyelination or granulomatous infiltration in the lateral horns of the spinal cord





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory