All Phenotypes Sprn<tm1Geno> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sprn^tm1Geno
targeted mutation 1, Genoway
MGI:5428663

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sprn^tm1Geno/Sprn^tm1Geno	involves: 129S2/SvPas * C57BL/6J	MGI:5428670
hm2	Sprn^tm1Geno/Sprn^tm1Geno	involves: 129S2/SvPas * C57BL/6J * FVB/NCr	MGI:5428671
cx3	Prnp^tm1Cwe/Prnp^tm1Cwe Sprn^tm1Geno/Sprn^tm1Geno	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N	MGI:5428672

Allelic Composition	Sprn^tm1Geno/Sprn^tm1Geno
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sprn^tm1Geno mutation (0 available); any Sprn mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:184837 )

N	• mice exhibit normal survival following prion infection

growth/size/body

decreased body weight ( J:184837 )

• in female mice between P8 and P16

increased body weight ( J:184837 )

• in male mice between P28 and P42

Allelic Composition	Sprn^tm1Geno/Sprn^tm1Geno
Genetic Background	involves: 129S2/SvPas * C57BL/6J * FVB/NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sprn^tm1Geno mutation (0 available); any Sprn mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:184837 )

• in male mice at P22

increased body weight ( J:184837 )

• in male mice between P29 and P50

Allelic Composition	Prnp^tm1Cwe/Prnp^tm1Cwe Sprn^tm1Geno/Sprn^tm1Geno
Genetic Background	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnp^tm1Cwe mutation (37 available); any Prnp mutation (142 available)
Sprn^tm1Geno mutation (0 available); any Sprn mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:184837 )

N	• mice exhibit normal survival unlike Prnp^tm1Cwe homozygotes

behavior/neurological

limb grasping ( J:184837 )

• as in Prnp^tm1Cwe homozygotes

tremors ( J:184837 )

• as in Prnp^tm1Cwe homozygotes

ataxia ( J:184837 )

• as in Prnp^tm1Cwe homozygotes

dysmetria ( J:184837 )

• as in Prnp^tm1Cwe homozygotes

nervous system

nervous system phenotype ( J:184837 )

N	• unlike Prnp^tm1Cwe homozygotes, mice do not exhibit dysmyelination or granulomatous infiltration in the lateral horns of the spinal cord

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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