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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Prrx1-FUS/DDIT3)1Mete
transgene insertion 1, Melissa Terry
MGI:5428676
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Trp53tm1Tyj/Trp53tm1Tyj
Tg(Prrx1-FUS/DDIT3)1Mete/0 		involves: 129S2/SvPas * C57BL/6 * CBA MGI:5430234
tg2
 		Tg(Prrx1-FUS/DDIT3)1Mete/0 involves: C57BL/6 * CBA MGI:5430233


Genotype
MGI:5430234
cx1
Allelic
Composition		 Trp53tm1Tyj/Trp53tm1Tyj
Tg(Prrx1-FUS/DDIT3)1Mete/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prrx1-FUS/DDIT3)1Mete mutation (1 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased sarcoma incidence ( J:184491 )
• predominantly in the appendicular skeleton
increased liposarcoma incidence ( J:184491 )
• mice develop myxoid round cell liposarcoma

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
myxoid liposarcoma DOID:5363 OMIM:613488
 J:184491




Genotype
MGI:5430233
tg2
Allelic
Composition		 Tg(Prrx1-FUS/DDIT3)1Mete/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prrx1-FUS/DDIT3)1Mete mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:184491 )
• mice are viable, fertile and do not form tumors




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory